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. 2016 May 26;2(1):e000224.
doi: 10.1136/rmdopen-2015-000224. eCollection 2016.

Translation of clinical problems in osteoarthritis into pathophysiological research goals

Peter M van der Kraan  1 , Francis Berenbaum  2 , Francisco J Blanco  3 , de Bari Cosimo  4 , Floris Lafeber  5 , Ellen Hauge  6 , Adele Higginbottom  7 , Andreea Ioan-Facsinay  8 , John Loughlin  9 , Ingrid Meulenbelt  10 , Eeva Moilanen  11 , Irene Pitsillidou  12 , Aspasia Tsezou  13 , Joyce van Meurs  14 , Tonia Vincent  15 , Ruth Wittoek  16 , Rik Lories  17 ; EULAR Study group in OA (http://www.eular.org/investigative_rheumatology_study_groups.cfm)
Affiliations

Translation of clinical problems in osteoarthritis into pathophysiological research goals

Peter M van der Kraan et al. RMD Open. .

Erratum in

Abstract

Osteoarthritis (OA) accounts for more disability among the elderly than any other disease and is associated with an increased mortality rate. The prevalence in Europe will rise in the future since this continent has a strongly ageing population and an obesity epidemic; obesity and age both being major risk factors for OA. No adequate therapeutic options, besides joint replacement, are available, although they are greatly needed and should be acquired by adequate research investments. However, the perspective on OA from a researcher's point of view is not always aligned with the perspective of a patient with OA. Researchers base their views on OA mainly on abnormalities in structure and function while patients consider OA as a collection of symptoms. In this viewpoint paper, we discuss the possibility of translating the most important clinical problems into pathophysiological research goals to facilitate the translation from bench to bedside and vice versa. This viewpoint is the outcome of a dialogue within the 'European League Against Rheumatism study group on OA' and People with Arthritis/Rheumatism across Europe (PARE) representatives.

Keywords: Osteoarthritis; Patient perspective; Qualitative research; Synovitis.

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