Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 May 25:4:53.
doi: 10.3389/fped.2016.00053. eCollection 2016.

Long-term Outcomes of Childhood Onset Nephrotic Syndrome

Rebecca Hjorten  1 , Zohra Anwar  1 , Kimberly Jean Reidy  1
Affiliations
Review

Long-term Outcomes of Childhood Onset Nephrotic Syndrome

Rebecca Hjorten et al. Front Pediatr. .

Abstract

There are limited studies on long-term outcomes of childhood onset nephrotic syndrome (NS). A majority of children with NS have steroid-sensitive nephrotic syndrome (SSNS). Steroid-resistant nephrotic syndrome (SRNS) is associated with a high risk of developing end-stage renal disease. Biomarkers and analysis of genetic mutations may provide new information for prognosis in SRNS. Frequently relapsing and steroid-dependent NS is associated with long-term complications, including dyslipidemia, cataracts, osteoporosis and fractures, obesity, impaired growth, and infertility. Long-term complications of SSNS are likely to be under-recognized. There remain many gaps in our knowledge of long-term outcomes of childhood NS, and further study is indicated.

Keywords: children; focal glomerulosclerosis; genetics; minimal-change disease; nephrotic syndrome; outcomes; pediatric.

PubMed Disclaimer

References

    1. Nephrotic syndrome in children: prediction of histopathology from clinical and laboratory characteristics at time of diagnosis. A report of the International Study of Kidney Disease in Children. Kidney Int (1978) 13(2):159–65. - PubMed
    1. The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children. J Pediatr (1981) 98(4):561–4. - PubMed
    1. Kaku Y, Ohtsuka Y, Komatsu Y, Ohta T, Nagai T, Kaito H, et al. Clinical practice guideline for pediatric idiopathic nephrotic syndrome 2013: general therapy. Clin Exp Nephrol (2015) 19(1):34–53.10.1007/s10157-014-1031-9 - DOI - PubMed
    1. Gipson DS, Trachtman H, Kaskel FJ, Radeva MK, Gassman J, Greene TH, et al. Clinical trials treating focal segmental glomerulosclerosis should measure patient quality of life. Kidney Int (2011) 79(6):678–85.10.1038/ki.2010.485 - DOI - PMC - PubMed
    1. Cattran DC, Rao P. Long-term outcome in children and adults with classic focal segmental glomerulosclerosis. Am J Kidney Dis (1998) 32(1):72–9.10.1053/ajkd.1998.v32.pm9669427 - DOI - PubMed

LinkOut - more resources