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Review
. 2016 Aug:32:82-88.
doi: 10.1016/j.mib.2016.05.003. Epub 2016 May 30.

(+) RNA virus replication compartments: a safe home for (most) viral replication

Ana Shulla  1 , Glenn Randall  2
Affiliations
Review

(+) RNA virus replication compartments: a safe home for (most) viral replication

Ana Shulla et al. Curr Opin Microbiol. 2016 Aug.

Abstract

This review describes recent advances in our understanding of the mechanisms by which (+) RNA viruses establish their replication niche.

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Figures

Figure 1
Figure 1
Host cell pathways involved in replication compartment formation of (+) RNA viruses. (a) Schematic illustration of an invagination replication compartment with overall negative membrane curvature. (b) Schematic illustration of a DMV replication compartment with overall positive membrane curvature. RTN: reticulon; LS: lipid synthesis; LTP: lipid transfer protein; ESCRT: endosomal sorting complexes required for transport; EE: early endosome.
See this image and copyright information in PMC

References

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    2. The authors use single molecule detection of (+) and (−) HCV RNAs to determine their spatiotemporal regulation during infection and reveal low levels of dsRNA intermediates before replication compartment formation.

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