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. 2016 Oct;32(7):672-674.
doi: 10.1002/dmrr.2833. Epub 2016 Jun 30.

Commentary: Mitochondrial DNA damage and loss in diabetes

Robert Gilkerson  1   2
Affiliations

Commentary: Mitochondrial DNA damage and loss in diabetes

Robert Gilkerson. Diabetes Metab Res Rev. 2016 Oct.

Abstract

This commentary discusses damage and loss of mitochondrial DNA (mtDNA) in type 2 diabetes mellitus from both the clinical and experimental perspectives. Increasingly, an array of studies in experimental models and patients suggests that the cellular stresses of insulin resistance in type 2 diabetes damage mtDNA, leading to loss of mitochondrial genetic content. As such, mtDNA is emerging as both a valuable monitoring tool and translational preventive target for metabolic disease. Copyright © 2016 John Wiley & Sons, Ltd.

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Conflict of interest statement

The author has nothing to disclose.

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