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Comment
. 2016 Jun 1;90(5):905-6.
doi: 10.1016/j.neuron.2016.05.027.

The Added Value of Family Material in the Discovery of Multiple Sclerosis Genes

Heather S Hain  1 , Hakon Hakonarson  2
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Free article
Comment

The Added Value of Family Material in the Discovery of Multiple Sclerosis Genes

Heather S Hain et al. Neuron. .
Free article

Abstract

A mutation in a nuclear receptor (NR1H3) gene was detected in a familial, progressive form of multiple sclerosis (PPMS). Further analyses showed a significant association between a common NR1H3 variant in PPMS patients and loss of function for the encoded protein.

Keywords: nuclear receptor; progressive multiple sclerosis.

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  • Nuclear Receptor NR1H3 in Familial Multiple Sclerosis.
    Wang Z, Sadovnick AD, Traboulsee AL, Ross JP, Bernales CQ, Encarnacion M, Yee IM, de Lemos M, Greenwood T, Lee JD, Wright G, Ross CJ, Zhang S, Song W, Vilariño-Güell C. Wang Z, et al. Neuron. 2016 Jun 1;90(5):948-54. doi: 10.1016/j.neuron.2016.04.039. Neuron. 2016. PMID: 27253448 Free PMC article.

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