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Clinical Trial
. 2016 Oct;35(10):1137-9.
doi: 10.1097/INF.0000000000001253.

Rotavirus Serum IgA Immune Response in Children Receiving Rotarix Coadministered With bOPV or IPV

Sasirekha Ramani  1 , Nora Mamani, Rodolfo Villena, Ananda S Bandyopadhyay, Chris Gast, Alicia Sato, Daniel Laucirica, Ralf Clemens, Mary K Estes, Miguel L O'Ryan
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Clinical Trial

Rotavirus Serum IgA Immune Response in Children Receiving Rotarix Coadministered With bOPV or IPV

Sasirekha Ramani et al. Pediatr Infect Dis J. 2016 Oct.

Abstract

Background: Vaccine schedules including bivalent oral and inactivated poliovirus vaccines will replace trivalent oral poliovirus vaccines in 2016.

Methods: We evaluated rotavirus immunoglobulin A seroresponses when the second dose of Rotarix at 16 weeks was given concomitantly with inactivated or bivalent oral poliovirus vaccines.

Results: Rotavirus immunoglobulin A seroresponse rate at week 28 was 15% lower in recipients of bivalent oral poliovirus vaccines compared with inactivated poliovirus vaccines.

Conclusion: Bivalent oral poliovirus vaccine decreases rotavirus IgA seroresponse rates when coadministered at 16 weeks of age.

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