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Case Reports
. 2016 Sep;35(9):1040-2.
doi: 10.1097/INF.0000000000001228.

Use of Ceftolozane/Tazobactam in the Treatment of Multidrug-resistant Pseudomonas aeruginosa Bloodstream Infection in a Pediatric Leukemia Patient

Samuel L Aitken  1 , Dimitrios P Kontoyiannis, April M DePombo, Micah M Bhatti, Frank P Tverdek, Suzanne C Gettys, David P Nicolau, Cesar A Nunez
Affiliations
Case Reports

Use of Ceftolozane/Tazobactam in the Treatment of Multidrug-resistant Pseudomonas aeruginosa Bloodstream Infection in a Pediatric Leukemia Patient

Samuel L Aitken et al. Pediatr Infect Dis J. 2016 Sep.

Abstract

Multidrug-resistant Pseudomonas aeruginosa is of increasing concern in pediatric patients. Ceftolozane/tazobactam is a novel cephalosporin/β-lactamase inhibitor combination with activity against multidrug-resistant Pseudomonas; however, no data exist on its use in children. This report summarizes the treatment of a multidrug-resistant P. aeruginosa bloodstream infection in a pediatric leukemia patient with ceftolozane/tazobactam and provides the first description of its pharmacokinetics in pediatrics.

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