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Review
. 2016 Jun 3:13:87.
doi: 10.1186/s12985-016-0544-0.

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir

Hamzah A Mohd  1 , Jaffar A Al-Tawfiq  2   3 , Ziad A Memish  4   5
Affiliations
Review

Middle East Respiratory Syndrome Coronavirus (MERS-CoV) origin and animal reservoir

Hamzah A Mohd et al. Virol J. .

Abstract

Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) is a novel coronavirus discovered in 2012 and is responsible for acute respiratory syndrome in humans. Though not confirmed yet, multiple surveillance and phylogenetic studies suggest a bat origin. The disease is heavily endemic in dromedary camel populations of East Africa and the Middle East. It is unclear as to when the virus was introduced to dromedary camels, but data from studies that investigated stored dromedary camel sera and geographical distribution of involved dromedary camel populations suggested that the virus was present in dromedary camels several decades ago. Though bats and alpacas can serve as potential reservoirs for MERS-CoV, dromedary camels seem to be the only animal host responsible for the spill over human infections.

Keywords: Animal; Bats; Camels; Coronavirus; Dromedary; MERS-CoV; Middle East; Middle East Respiratory Syndrome.

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References

    1. Zaki AM, Boheemena S, Bestebroer TIM, Osterhaus A, Fouchier R. Isolation of a novel coronavirus from a man with pneumonia in Saudi Arabia. N Engl J Med. 2012;367:1814–20. doi: 10.1056/NEJMoa1211721. - DOI - PubMed
    1. Command and Control Center (CCC) Statistics – April 2016.Ministry of Health (MOH) –Kingdom of Saudi Arabia. http://www.moh.gov.sa/en/CCC/PressReleases/Pages/default.aspx. Accessed 15 Apr 2016.
    1. Tyrel DA, Bynoe ML. Cultivation of a novel type of common cold virus in organ culture. Br Med J. 1965;1(5448):1467–70. doi: 10.1136/bmj.1.5448.1467. - DOI - PMC - PubMed
    1. Chan JF, Lau SK, To KK, Cheng VC, Woo PC, Yuen KY. Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease. Clin Microbiol Rev. 2015;28:465–522. doi: 10.1128/CMR.00102-14. - DOI - PMC - PubMed
    1. Boheemena S, Graafa M, Lauberb C, Bestebroera TM, Raja S, Zaki AM, et al. Genomic characterization of a newly discovered coronavirus associated with acute respiratory distress syndrome in humans. mBio 3(6). doi: 10.1128/mBio.00473-12. - PMC - PubMed

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