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Editorial
. 2016 Jun;14(3):172-175.
doi: 10.1016/j.gpb.2016.05.003. Epub 2016 May 30.

New Edges of RNA Adenosine Methylation Modifications

Ye Wang  1 , Guifang Jia  2
Affiliations
Editorial

New Edges of RNA Adenosine Methylation Modifications

Ye Wang et al. Genomics Proteomics Bioinformatics. 2016 Jun.
No abstract available

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Figures

Figure 1
Figure 1
A proposed model of pre-mRNA splicing regulated by YTHDC1 Under the conditions that m6A in pre-mRNA is recognized by YTHDC1, YTHDC1 recruits SRSF3 to promote exon inclusion; under the conditions that pre-mRNA does not contain m6A or pre-mRNA with m6A is not bound by YTHDC1, SRSF10 facilitates exon skipping. YTHDC1, YTH domain-containing protein 1; SRSF, serine/arginine-rich splicing factor.
Figure 2
Figure 2
Schematic outline of m1A-seq and m1A-ID-seq In m1A-seq, mismatch rates caused by m1A (untreated sample) and m6A (chemical rearrangement) were compared. In m1A-ID-seq, cDNA truncations conferred by m1A (untreated sample) were compared to full-length cDNA (demethylation to A). IP, immunoprecipitation; RT, reverse transcription.
See this image and copyright information in PMC

References

    1. Xiao W., Adhikari S., Dahal U., Chen Y.S., Hao Y.J., Sun B.F. Nuclear m6A reader YTHDC1 regulates mRNA splicing. Mol Cell. 2016;61:507–519. - PubMed
    1. Dominissini D., Nachtergaele S., Moshitch-Moshkovitz S., Peer E., Kol N., Ben-Haim M.S. The dynamic N1-methyladenosine methylome in eukaryotic messenger RNA. Nature. 2016;530:441–446. - PMC - PubMed
    1. Li X., Xiong X., Wang K., Wang L., Shu X., Ma S. Transcriptome-wide mapping reveals reversible and dynamic N1-methyladenosine methylome. Nat Chem Biol. 2016;12:311–316. - PubMed
    1. Yue Y., Liu J., He C. RNA N6-methyladenosine methylation in post-transcriptional gene expression regulation. Genes Dev. 2015;29:1343–1355. - PMC - PubMed
    1. Jia G., Fu Y., Zhao X., Dai Q., Zheng G., Yang Y. N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO. Nat Chem Biol. 2011;7:885–887. - PMC - PubMed

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