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. 2016 Oct;32(10):755-757.
doi: 10.1016/j.pt.2016.05.011. Epub 2016 May 30.

Leishmania DNA Replication Timing: A Stochastic Event?

Maria C Rocha-Granados  1 , Michele M Klingbeil  2
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Leishmania DNA Replication Timing: A Stochastic Event?

Maria C Rocha-Granados et al. Trends Parasitol. 2016 Oct.

Abstract

For eukaryotic genomes, DNA synthesis initiates at multiple discrete regions known as replication origins in a dynamic yet regulated manner to ensure genomic stability. Two recent studies using different approaches reveal few Leishmania origins and that origin firing may proceed in a mainly stochastic manner.

Keywords: DNA replication; Leishmania; aneuploidy; origin of replication; stochastic timing.

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