Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Jul;16(7):463-78.
doi: 10.1038/nrc.2016.49. Epub 2016 Jun 3.

The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target

Xiao Zhen Zhou  1 , Kun Ping Lu  1
Affiliations
Review

The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target

Xiao Zhen Zhou et al. Nat Rev Cancer. 2016 Jul.

Abstract

Targeted drugs have changed cancer treatment but are often ineffective in the long term against solid tumours, largely because of the activation of heterogeneous oncogenic pathways. A central common signalling mechanism in many of these pathways is proline-directed phosphorylation, which is regulated by many kinases and phosphatases. The structure and function of these phosphorylated proteins are further controlled by a single proline isomerase: PIN1. PIN1 is overactivated in cancers and it promotes cancer and cancer stem cells by disrupting the balance of oncogenes and tumour suppressors. This Review discusses the roles of PIN1 in cancer and the potential of PIN1 inhibitors to restore this balance.

PubMed Disclaimer

References

    1. Cell. 2009 Aug 7;138(3):592-603 - PubMed
    1. Nature. 1999 Jun 24;399(6738):784-8 - PubMed
    1. EMBO J. 2001 Jul 2;20(13):3459-72 - PubMed
    1. Cancer Res. 2003 Oct 1;63(19):6244-51 - PubMed
    1. Mol Cancer Ther. 2010 Mar;9(3):606-16 - PubMed

Substances

LinkOut - more resources