Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Sep;15(9):639-660.
doi: 10.1038/nrd.2016.75. Epub 2016 Jun 3.

Targeting adipose tissue in the treatment of obesity-associated diabetes

Christine M Kusminski  1 , Perry E Bickel  2 , Philipp E Scherer  1
Affiliations
Review

Targeting adipose tissue in the treatment of obesity-associated diabetes

Christine M Kusminski et al. Nat Rev Drug Discov. 2016 Sep.

Abstract

Adipose tissue regulates numerous physiological processes, and its dysfunction in obese humans is associated with disrupted metabolic homeostasis, insulin resistance and type 2 diabetes mellitus (T2DM). Although several US-approved treatments for obesity and T2DM exist, these are limited by adverse effects and a lack of effective long-term glucose control. In this Review, we provide an overview of the role of adipose tissue in metabolic homeostasis and assess emerging novel therapeutic strategies targeting adipose tissue, including adipokine-based strategies, promotion of white adipose tissue beiging as well as reduction of inflammation and fibrosis.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Diabetes. 2010 Oct;59(10):2453-64 - PubMed
    1. Annu Rev Nutr. 2014;34:207-36 - PubMed
    1. Nat Med. 2013 Oct;19(10):1338-44 - PubMed
    1. Nat Med. 2011 Feb;17(2):200-5 - PubMed
    1. Endocrinology. 2009 Jul;150(7):3083-91 - PubMed