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. 1989 Jun 8;339(6224):446-51.
doi: 10.1038/339446a0.

Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

S F Tsai  1 , D I Martin, L I Zon, A D D'Andrea, G G Wong, S H Orkin
Affiliations

Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells

S F Tsai et al. Nature. .

Abstract

Genes expressed in erythroid cells contain binding sites for a cell-specific factor believed to be an important regulator for this haematopoietic lineage. Using high-level transient expression in mammalian cells, we have identified complementary DNA encoding the murine protein. The factor, a new member of the zinc-finger family of DNA-binding proteins, is restricted to erythroid cells at the level of RNA expression and is closely homologous between mouse and man.

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