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. 2016 Jun;10(3):97-106.
doi: 10.1049/iet-nbt.2015.0006.

Evaluation of the effect of time on the distribution of zinc oxide nanoparticles in tissues of rats and mice: a systematic review

Aijie Chen  1 , Xiaoli Feng  1 , Ting Sun  2 , Yanli Zhang  1 , Shengli An  3 , Longquan Shao  4
Affiliations

Evaluation of the effect of time on the distribution of zinc oxide nanoparticles in tissues of rats and mice: a systematic review

Aijie Chen et al. IET Nanobiotechnol. 2016 Jun.

Abstract

To evaluate the time effect on the distribution of zinc oxide nanoparticles (ZnO NPs) in tissues from rats and mice, a search on the PubMed, Embase, SpringerLink, Scopus, Science Direct, Cochrane, CNKI, Wanfang, and vip databases up to September 2014 was performed, followed by screening, data extraction, and quality assessment. Thirteen studies were included. At 24 h, Zn content was mainly distributed in the liver, kidney, and lung. At ≥7 days, Zn content was mainly distributed in the liver, kidney, lung, and brain. ZnO NPs are readily deposited in tissues. Furthermore, as time increases, Zn content decreases in the liver and kidney, but increases in the brain.

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Flow diagram for the study selection
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