Tumor Organoids Fill the Niche
- PMID: 27257754
- DOI: 10.1016/j.stem.2016.05.020
Tumor Organoids Fill the Niche
Abstract
Organoid technologies have significant potential as effective patient avatars. Fujii et al. (2016) and van de Wetering et al. (2015) derive biobanks of colorectal tumor and matching normal organoids and identify associations between tumor subtype, oncogenic drivers, gene-drug interactions, and varying niche requirements for tumor organoid growth, engraftment, and metastasis.
Copyright © 2016 Elsevier Inc. All rights reserved.
Comment on
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Prospective derivation of a living organoid biobank of colorectal cancer patients.Cell. 2015 May 7;161(4):933-45. doi: 10.1016/j.cell.2015.03.053. Cell. 2015. PMID: 25957691 Free PMC article.
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A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis.Cell Stem Cell. 2016 Jun 2;18(6):827-838. doi: 10.1016/j.stem.2016.04.003. Epub 2016 May 19. Cell Stem Cell. 2016. PMID: 27212702
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