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. 2016 Jun 2;18(6):699-702.
doi: 10.1016/j.stem.2016.05.014.

Closing in on Mass Production of Mature Human Beta Cells

Timothy J Kieffer  1
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Free article

Closing in on Mass Production of Mature Human Beta Cells

Timothy J Kieffer. Cell Stem Cell. .
Free article

Abstract

Human pluripotent stem cell differentiation protocols based on mimicking developmental pathways are getting close to generating fully fledged pancreatic endocrine cells, including insulin-producing beta cells. However, challenges remain in identifying pathways to trigger the attainment of robust glucose responsiveness that occurs postnatally in beta cells.

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