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Review
. 2016 Jun 2;62(5):745-55.
doi: 10.1016/j.molcel.2016.05.003.

DNA Replication-A Matter of Fidelity

Rais A Ganai  1 , Erik Johansson  2
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Free article
Review

DNA Replication-A Matter of Fidelity

Rais A Ganai et al. Mol Cell. .
Free article

Abstract

The fidelity of DNA replication is determined by many factors, here simplified as the contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch repair, a balanced supply of nucleotides, and the condition of the DNA template (both in terms of sequence context and the presence of DNA lesions). This review discusses the contribution and interplay between these factors to the overall fidelity of DNA replication.

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