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Comment
. 2016 Jun;6(6):576-8.
doi: 10.1158/2159-8290.CD-16-0485.

Senescence Can Be BETter without the SASP?

Maria Grazia Vizioli  1 , Peter D Adams  2
Affiliations
Comment

Senescence Can Be BETter without the SASP?

Maria Grazia Vizioli et al. Cancer Discov. 2016 Jun.

Abstract

Global remodeling of the chromatin landscape occurs during senescence, although its functional consequence is still unclear. In this issue, Tasdemir and colleagues show that the epigenetic regulator BRD4 is required for expression of the proinflammatory senescence-associated secretory phenotype and immune clearance of senescent cells in vitro and in vivo Their results could be useful in the design of novel therapies to treat aging-related diseases, including cancer.Cancer Discov; 6(6); 576-8. ©2016 AACR.See related article by Tasdemir et al., p. 612.

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Conflict of interest statement

The authors disclose no potential conflicts of interest.

Figures

Figure 1
Figure 1. BRD4 is required for the execution of the senescence program
(Top) Lowe and colleagues show that BRD4 regulates SASP expression and immune surveillance during OIS. (Bottom) Genetic or pharmacologic inactivation of BRD4 (by shRNA or BET inhibitors) breaks this link and causes the collapse of this tumour-suppressive mechanism.
See this image and copyright information in PMC

Comment on

  • BRD4 Connects Enhancer Remodeling to Senescence Immune Surveillance.
    Tasdemir N, Banito A, Roe JS, Alonso-Curbelo D, Camiolo M, Tschaharganeh DF, Huang CH, Aksoy O, Bolden JE, Chen CC, Fennell M, Thapar V, Chicas A, Vakoc CR, Lowe SW. Tasdemir N, et al. Cancer Discov. 2016 Jun;6(6):612-29. doi: 10.1158/2159-8290.CD-16-0217. Epub 2016 Apr 20. Cancer Discov. 2016. PMID: 27099234 Free PMC article.

References

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