Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2016 Aug;41(8):679-689.
doi: 10.1016/j.tibs.2016.05.004. Epub 2016 Jun 1.

Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)

Pankaj Kumar  1 , Canan Kuscu  1 , Anindya Dutta  2
Affiliations
Review

Biogenesis and Function of Transfer RNA-Related Fragments (tRFs)

Pankaj Kumar et al. Trends Biochem Sci. 2016 Aug.

Abstract

Noncoding small RNAs arise from the various un-annotated and annotated regions of the genome. When they arise from annotated genes, the noncoding small RNAs are functionally different from the parent genes. This is a brief review of one class of noncoding small RNAs, tRNA-related fragments (tRFs), which are generated from tRNA. tRFs have been suggested to have roles in cell proliferation, priming of viral reverse transcriptases, regulation of gene expression, RNA processing, modulation of the DNA damage response, tumor suppression, and neurodegeneration.

Keywords: non-coding small RNA; tRF; tRFdb; tRNA.

PubMed Disclaimer

Figures

Figure 1
Figure 1. Classification of tRNA derived fragments (tRFs)
Fragments from tRNAs color coded to indicate area of origin. White circles indicate an intron present in some tRNAs (e.g. chr16.trna4-ProAGG) that is normally spliced out by TSEN and CLP1. tRF2 is a class proposed in this review.
See this image and copyright information in PMC

References

    1. Lee RC, et al. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell. 1993;75:843–854. - PubMed
    1. Wightman B, et al. Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell. 1993;75:855–862. - PubMed
    1. Kozomara A, Griffiths-Jones S. miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res. 2011;39:D152–157. - PMC - PubMed
    1. Lee YS, et al. A novel class of small RNAs: tRNA-derived RNA fragments (tRFs) Genes Dev. 2009;23:2639–2649. - PMC - PubMed
    1. Pederson T. Regulatory RNAs derived from transfer RNA? Rna. 2010;16:1865–1869. - PMC - PubMed

Publication types

MeSH terms

Substances