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Review
. 2017 Mar;19(1):1-10.
doi: 10.1007/s12017-016-8417-7. Epub 2016 Jun 4.

mTOR Signaling in Parkinson's Disease

Ai-Ping Lan  1 , Jun Chen  1 , Yuliang Zhao  1 , Zhifang Chai  1 , Yi Hu  2
Affiliations
Review

mTOR Signaling in Parkinson's Disease

Ai-Ping Lan et al. Neuromolecular Med. 2017 Mar.

Abstract

As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson's disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms underlying mTOR-mediated effects in PD have not been fully understood yet. Here, we review recent progress in characterizing the association of mTOR signaling with PD risk factors and further discuss the potential roles of mTOR in PD.

Keywords: Apoptosis; Oxidative stress; Parkinson’s disease; mTOR; α-Synuclein.

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References

    1. Nat Cell Biol. 2002 Sep;4(9):648-57 - PubMed
    1. Nat Cell Biol. 2002 Sep;4(9):699-704 - PubMed
    1. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13571-6 - PubMed
    1. Mol Cell. 2002 Sep;10(3):457-68 - PubMed
    1. J Biol Chem. 2003 Jul 4;278(27):25009-13 - PubMed

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