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Review
. 2016 Jun;137(6):1671-1673.
doi: 10.1016/j.jaci.2016.04.004. Epub 2016 Apr 23.

The discovery of IgE

S G O Johansson  1
Affiliations
Review

The discovery of IgE

S G O Johansson. J Allergy Clin Immunol. 2016 Jun.

Abstract

In 1919, the search began for the factor, later called reagin, that could mediate an allergy, such as allergic asthma, in sera of allergic subjects. In 1967, the fifth class of immunoglobulins, IgE, was discovered and found to be able to carry reagin activity. This discovery has had immense importance for the understanding, diagnosis, and treatment of allergic diseases.

Keywords: Allergy; immunoglobulin; inflammation; mast cell; reagin; sensitization.

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