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. 2011 Jun 5;28(2):142-5.
doi: 10.5152/tjh.2011.32.

Are cup-like blasts specific to AML patients with FLT3 ITD and a normal karyotype? An ALL case report and review of the literature

Özgür Mehtap  1 , Elif Birtaş Ateşoğlu, Emel Gönüllü, Hakan Keski, Abdullah Hacıhanefioğlu
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Free article

Are cup-like blasts specific to AML patients with FLT3 ITD and a normal karyotype? An ALL case report and review of the literature

Özgür Mehtap et al. Turk J Haematol. .
Free article

Abstract
in English, Turkish

Cup-like morphology is defined as cup-like nuclear invagination spanning ≥25% of the nuclear diameter in >10% of blasts. Studies have shown that FLT3 ITD and normal cytology are strongly associated with cup-like morphology in acute myeloid leukemia (AML) patients. Herein we describe a patient with cup-like blasts that was diagnosed and treated for common acute lymphoblastic leukemia (ALL). In contrast to the literature, the presented case was Philadelphia chromosome positive and FLT3 ITD negative.

Cup-like morfoloji, blastların %10’unda fazlasında bulunan, blast çekirdeği çapının, en az %25’ini kapsayan, çekirdeğin içe doğru kıvrılması olarak tanımlanır. Çalışmalarda AML hastalarındaki cup-like morfolojinin, FLT3 ITD ve normal sitogenetik ile güçlü bir ilişkisi olduğu gösterilmiştir. Bu çalışmada Common akut lenfoblastik lösemi tanısı alan ve tedavisi buna göre düzenlenen, cup-like blastları olan bir hasta sunulmuştur. Literatürün aksine bizim hastamızda Philadelphia kromozomu pozitif ve FLT3 ITD negative tespit ettik.

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