doi: 10.1007/BF00581820.
Calcium-induced calcium release activates contraction in intact cardiac cells
Affiliations
- PMID: 2726431
- DOI: 10.1007/BF00581820
Item in Clipboard
Calcium-induced calcium release activates contraction in intact cardiac cells
Pflugers Arch.
1989 Apr.
Abstract
The "caged" calcium chelator Nitr-5 was incorporated into isolated rat ventricular myocytes. Brief illumination with ultra-violet light made the cell twitch. The light-induced twitch was inhibited by ryanodine (1-10/microM) suggesting that it resulted from calcium-induced release of calcium from the sarcoplasmic reticulum. Inhibition of the Ca current (Ni, 10 mM) abolished the electrically stimulated twitch but did not inhibit the light-induced twitch. These results provide direct evidence for the importance of Ca-induced Ca release in excitation-contraction coupling in the heart.
Similar articles
-
Spontaneous Ca2+ release from the sarcoplasmic reticulum limits Ca2+-dependent twitch potentiation in individual cardiac myocytes. A mechanism for maximum inotropy in the myocardium.J Gen Physiol. 1988 Jan;91(1):133-55. doi: 10.1085/jgp.91.1.133. J Gen Physiol. 1988. PMID: 3343586 Free PMC article.
-
A role for depolarisation induced calcium entry on the Na-Ca exchange in triggering intracellular calcium release and contraction in rat ventricular myocytes.Cardiovasc Res. 1993 Sep;27(9):1677-90. doi: 10.1093/cvr/27.9.1677. Cardiovasc Res. 1993. PMID: 8287448
-
Ca flux, contractility, and excitation-contraction coupling in hypertrophic rat ventricular myocytes.Am J Physiol. 1998 Apr;274(4):H1348-60. doi: 10.1152/ajpheart.1998.274.4.H1348. Am J Physiol. 1998. PMID: 9575940
-
Calcium handling by sarcoplasmic reticulum of neonatal swine cardiac myocytes.Am J Physiol. 1997 Jul;273(1 Pt 2):H192-9. doi: 10.1152/ajpheart.1997.273.1.H192. Am J Physiol. 1997. PMID: 9249490
-
The 1996 Merck Frosst Award. The voltage-sensitive release mechanism: a new trigger for cardiac contraction.Can J Physiol Pharmacol. 1997 Sep;75(9):1044-57. doi: 10.1139/cjpp-75-9-1044. Can J Physiol Pharmacol. 1997. PMID: 9365812 Review.
Cited by
-
[Ca2+]i waves in heart cells: more than a passing fancy.Biophys J. 1993 Dec;65(6):2270-1. doi: 10.1016/S0006-3495(93)81287-6. Biophys J. 1993. PMID: 8312467 Free PMC article. No abstract available.
-
The effect of internal sodium and caesium on phasic contraction of patch-clamped rabbit ventricular myocytes.J Physiol. 1996 Apr 1;492 ( Pt 1)(Pt 1):1-19. doi: 10.1113/jphysiol.1996.sp021284. J Physiol. 1996. PMID: 8730578 Free PMC article.
-
Local control of excitation-contraction coupling in rat heart cells.J Physiol. 1994 Feb 1;474(3):463-71. doi: 10.1113/jphysiol.1994.sp020037. J Physiol. 1994. PMID: 8014907 Free PMC article.
-
Calcium transients caused by calcium entry are influenced by the sarcoplasmic reticulum in guinea-pig atrial myocytes.J Physiol. 1992 Aug;454:321-38. doi: 10.1113/jphysiol.1992.sp019266. J Physiol. 1992. PMID: 1335504 Free PMC article.
-
Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders.Prog Neurobiol. 2015 Nov;134:36-54. doi: 10.1016/j.pneurobio.2015.09.002. Epub 2015 Sep 16. Prog Neurobiol. 2015. PMID: 26386135 Free PMC article. Review.