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. 1978 Jan;75(1):298-302.
doi: 10.1073/pnas.75.1.298.

Molecular mechanisms for proton transport in membranes

J F Nagle, H J Morowitz

Molecular mechanisms for proton transport in membranes

J F Nagle et al. Proc Natl Acad Sci U S A. 1978 Jan.

Abstract

Likely mechanisms for proton transport through biomembranes are explored. The fundamental structural element is assumed to be continuous chains of hydrogen bonds formed from the protein side groups, and a molecular example is presented. From studies in ice, such chains are predicted to have low impedance and can function as proton wires. In addition, conformational changes in the protein may be linked to the proton conduction. If this possibility is allowed, a simple proton pump can be described that can be reversed into a molecular motor driven by an electrochemical potential across the membrane.

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References

    1. J Membr Biol. 1976 Dec 28;30(2):121-34 - PubMed
    1. Biosystems. 1977 Apr;8(4):207-12 - PubMed
    1. J Biol Chem. 1976 Nov 25;251(22):7059-65 - PubMed
    1. Biochim Biophys Acta. 1976 Apr 30;456(1):39-84 - PubMed
    1. Annu Rev Biophys Bioeng. 1977;6:87-109 - PubMed

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