Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jun;33(3):365-8.
doi: 10.3760/cma.j.issn.1003-9406.2016.03.020.

[Association of polymorphisms of miRNA biogenesis related genes DICER and DROSHA with azoospermia]

[Article in Chinese]
Mei Fu  1 , Kehui Xu, Junjie Ye, Wenming Xu
Affiliations

[Association of polymorphisms of miRNA biogenesis related genes DICER and DROSHA with azoospermia]

[Article in Chinese]
Mei Fu et al. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016 Jun.

Abstract

Objective: To assess the association of polymorphisms of miRNA biogenesis related genes DICER and DROSHA with azoospermia.

Methods: For 330 patients with primary azoospermia and 282 fertile male controls, single nucleotide polymorphisms (SNPs) of DICER rs3742330 and DROSHA rs10719 were determined with a restriction fragment length polymorphism (RFLP) method.

Results: For the SNP rs3742330, the frequency of A allele was higher among azoospermia patients compared with the controls (72.0% vs.64.4%, P=0.004), and so was the frequency of AA genotype (53.0% vs. 41.8%, P=0.027, OR=1.829, 95%CI: 1.071-3.124). On the other hand, the allelic and genotypic frequencies of rs10719 did not differ between the two groups (all P > 0.05).

Conclusion: Polymorphisms of rs3742330 of the DICER gene, particularly the AA genotype, may be associated with azoospermia.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

Publication types

LinkOut - more resources