doi: 10.1073/pnas.75.1.50.
Structure of the orgin of DNA replication of bacteriophage fd
- PMID: 272666
- PMCID: PMC411181
- DOI: 10.1073/pnas.75.1.50
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Structure of the orgin of DNA replication of bacteriophage fd
Proc Natl Acad Sci U S A.
1978 Jan.
Abstract
An RNA-polymerase-protected DNA fragment of 125 nucleotides from the origin of single-strand to double-strand replication of bacteriophage fd (ori-DNA) was located on the physical map of the phage genome. A stretch of 187 base pairs of DNA including the ori-DNA was sequenced. This DNA segment contains regions with a highly asymmetric pyrimidine/purine distribution next to regions with 2-fold symmetry that form stable hairpin structures in the viral DNA strand.
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