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. 2016 Jun 6:16:128.
doi: 10.1186/s12872-016-0305-4.

Arterial stiffness in patients with coronary artery disease: relation with in-stent restenosis following percutaneous coronary intervention

Affiliations

Arterial stiffness in patients with coronary artery disease: relation with in-stent restenosis following percutaneous coronary intervention

Zrinko Prskalo et al. BMC Cardiovasc Disord. .

Abstract

Background: Coronary artery disease (CAD) is one of the most important issues in modern medicine due to its high mortality and prevalence. An early detection and prevention can reduce morbidity and mortality. Arterial stiffness is a potent and independent predictor of CAD. We aimed to investigate the arterial stiffness in CAD patients undergoing the coronary angiography. Also, we investigated a possible correlation between arterial stiffness and in-stent restenosis (ISR), an important limitation of percutaneous coronary intervention (PCI).

Methods: The study included 160 patients undergoing coronary angiography, treated either with PCI or with CABG. The pulse wave velocity (PWV) and augmentation index (AIx) were measured by the Arteriograph.

Results: PWV in the CAD group (12.24 ± 2.78 m/s) was significantly higher compared to the control group (8.27 ± 1.89 m/s). PWV in ISR and left main (LM) stenosis group (14.03 ± 3.15 and 13.89 ± 2.95 m/s) was significantly higher compared to the control and CAD groups. Peripheral and central AIx were significantly higher in CAD group (1.38 ± 30.63 % and 38.35 ± 15.52 %) than in control group (-11.35 ± 26.74 % and 26.91 ± 10.62 %). Patients with LM stenosis have significantly higher values of peripheral and central AIx (23.37 ± 23.77 % and 49.71 ± 12.02 %) than the CAD and ISR group.

Conclusions: The study confirmed a positive correlation between arterial stiffness measures, PWV and AIx, and CAD. Also, this study showed the correlation between PWV and ISR which can help to select more appropriate stent.

Keywords: Coronary artery disease; Coronary restenosis; Vascular stiffness.

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Figures

Fig. 1
Fig. 1
The values of aortic pulse wave velocity (PWV) in the control, coronary artery disease (CAD), in-stent restenosis (ISR) and left main stenosis group. Data are shown as mean ± SD, * p <0.05 vs control group, # p <0.05 vs CAD group
Fig. 2
Fig. 2
The values of aortic augmentation index (AIx), expressed in percentages in the control, coronary artery disease (CAD), in stent restenosis (ISR) and left main stenosis group. Data are shown as mean ± SD, * p <0.05 vs control group, # p <0.05 vs CAD and ISR groups
Fig. 3
Fig. 3
The difference between the brachial augmentation index (AIx) in control, coronary artery disease (CAD), in stent restenosis (ISR) and left main stenosis group. Data are shown as mean ± SD, * p <0.05 vs control group, # p <0.05 vs CAD and ISR groups

References

    1. Bonnefoy E, Kirkorian G. Mortality of myocardial infarction. Ann Cardiol Angeiol (Paris) 2011;60:311–316. doi: 10.1016/j.ancard.2011.10.001. - DOI - PubMed
    1. De Backer G, Ambrosioni E, Borch-Johnsen K, Brotons C, Cifkova R, Dallongeville J, et al. European guidelines on cardiovascular disease prevention in clinical practice. Third Joint Task Force of European and Other Societies on Cardiovascular Disease Prevention in Clinical Practice. Eur Heart J. 2003;24:1601–1610. doi: 10.1016/S0195-668X(03)00347-6. - DOI - PubMed
    1. Shirwany NA, Zou MH. Arterial stiffness: a brief review. Acta Pharmacol Sin. 2010;31:1267–1276. doi: 10.1038/aps.2010.123. - DOI - PMC - PubMed
    1. Weber T, Auer J, O’Rourke MF, Kvas E, Lassnig E, Berent R, et al. Arterial stiffness, wave reflections, and the risk of coronary artery disease. Circulation. 2004;109:184–189. doi: 10.1161/01.CIR.0000105767.94169.E3. - DOI - PubMed
    1. Vlachopoulos C, Aznaouridis K, Stefanadis C. Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol. 2010;55:1318–1327. doi: 10.1016/j.jacc.2009.10.061. - DOI - PubMed

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