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. 1989 Mar;6(3):252-4.
doi: 10.1023/a:1015925803166.

The antiarrhythmic activity of N-alkyl-1,2-diphenylethanolamines

K E el Tahir  1 , H A al-Obeid, K A al-Rashood, A A Madani, A M Ageel
Affiliations

The antiarrhythmic activity of N-alkyl-1,2-diphenylethanolamines

K E el Tahir et al. Pharm Res. 1989 Mar.

Abstract

The activity of N-alkyl-1,2-diphenylethanolamines against CaCl2-induced cardiac arrhythmia was evaluated in the rat. The potencies of the compounds were compared with that of the established calcium ion-channel blocker, verapamil. The N-methyl, N-ethyl, and N-isobutyl derivatives as well as verapamil at doses of 2-8 mumols kg-1 protected the animals against the induced arrhythmia. The potency order was verapamil greater than N methyl greater than N-ethyl greater than N-isobutyl derivatives. The N-isopropyl and N-butyl derivatives were inactive. The antiarrhythmic activity of the compounds was not due to local anesthetic activity but may be caused by calcium-channel inhibition.

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