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Case Reports
. 2016 Sep;138(3):903-905.
doi: 10.1016/j.jaci.2016.02.040. Epub 2016 Apr 24.

Persistent nodal histoplasmosis in nuclear factor kappa B essential modulator deficiency: Report of a case and review of infection in primary immunodeficiencies

Jana P Lovell  1 , Ladan Foruraghi  1 , Alexandra F Freeman  1 , Gulbu Uzel  1 , Christa S Zerbe  1 , Helen Su  2 , Amy P Hsu  1 , Steven M Holland  3
Affiliations
Case Reports

Persistent nodal histoplasmosis in nuclear factor kappa B essential modulator deficiency: Report of a case and review of infection in primary immunodeficiencies

Jana P Lovell et al. J Allergy Clin Immunol. 2016 Sep.

Abstract

In the absence of acquired or secondary immunosuppression, mutations causing failure to properly activate the IL-12/IFN-γ pathway, NF-κB, or STAT3 should be excluded in patients presenting with severe histoplasmosis.

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Figures

Figure 1
Figure 1
A) Coronal CT with contrast showing superior perihilar mass. B) Grocott’s methenamine silver stain of right paratracheal lymph node showing a small yeast form.
See this image and copyright information in PMC

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