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Review
. 2016 Oct 21;37(40):3075-3080.
doi: 10.1093/eurheartj/ehw206. Epub 2016 Jun 5.

DNA damage-associated biomarkers in studying individual sensitivity to low-dose radiation from cardiovascular imaging

Won Hee Lee  1   2   3 , Patricia K Nguyen  4   2   3 , Dominik Fleischmann  2   3 , Joseph C Wu  1   2   3
Affiliations
Review

DNA damage-associated biomarkers in studying individual sensitivity to low-dose radiation from cardiovascular imaging

Won Hee Lee et al. Eur Heart J. .
No abstract available

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Figures

Figure 1
Figure 1
Overview of the DNA damage-associated biomarkers of ionizing radiation. Multiple types of biomarkers are available for measuring radiation exposure and monitoring the DNA damage and repair, such as cytogenetic, proteomic, genomic, and epigenomic biomarkers. ATM, ataxia-telangiectasia mutated; DSBs, double-strand breaks; lncRNA, long non-coding RNA; miRNA, microRNA; p, phosphate group; p53, tumour protein p53; SNPs, single nucleotide polymorphisms.
Figure 2
Figure 2
Schematic of a donor-specific cell-based platform for predicting individual radiosensitivity. Induced pluripotent stem cells obtained through the reprogramming of somatic cells from an individual can be differentiated into various cell types. Different cell types from the same individual can then be exposed to radiation for measurement of cellular responses in vitro using multiple biomarkers. iPSCs, induced pluripotent stem cells; RT, radiation; DNA DSBs, DNA double-strand breaks.
See this image and copyright information in PMC

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