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. 2016 May 10:9:137-44.
doi: 10.2147/DMSO.S101283. eCollection 2016.

Metabolic syndrome and C-reactive protein in bank employees

Monica Cattafesta  1 , Nazaré Souza Bissoli  2 , Luciane Bresciani Salaroli  3
Affiliations

Metabolic syndrome and C-reactive protein in bank employees

Monica Cattafesta et al. Diabetes Metab Syndr Obes. .

Abstract

Background: The ultrasensitive C-reactive protein (us-CRP) is used for the diagnosis of cardiovascular disease, but it is not well described as a marker for the diagnosis of metabolic syndrome (MS).

Methods: An observational and transversal study of bank employees evaluated anthropometric, hemodynamic, and biochemical data. CRP values were determined using commercial kits from Roche Diagnostics Ltd, and MS criteria were analyzed according to National Cholesterol Education Program's - Adult Treatment Panel III (NCEP/ATP III).

Results: A total of 88 individuals had MS, and 77.3% (n=68) of these showed alterations of us-CRP (P=0.0001, confidence interval [CI] 0.11-0.34). Individuals with MS had higher mean values of us-CRP in global measures (P=0.0001) and stratified by sex (P=0.004) than individuals without the syndrome. This marker exhibited significant differences with varying criteria for MS, such as waist circumference (P=0.0001), triglycerides (P=0.002), and diastolic blood pressure (P=0.007), and the highest levels of us-CRP were found in individuals with more MS criteria.

Conclusion: us-CRP was strongly associated with the presence of MS and MS criteria in this group of workers. us-CRP is a useful and effective marker for identifying the development of MS and may be used as a reference in routine care.

Keywords: C-reactive protein; bank employees; inflammation mediators; metabolic syndrome; occupational health.

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Figures

Figure 1
Figure 1
Serum levels of us-CRP in bank employees with and without MS stratified in general (A) and by sex (B). Notes: Data are presented as the mean values. Study undertaken in Vitória, Espírito Santo, Brazil, in 2016. Abbreviations: MS, metabolic syndrome; us-CRP, ultrasensitive C-reactive protein.
Figure 2
Figure 2
us-CRP level quartiles for bank employees according to the prevalence of MS stratified by sex (female [A] and male [B]) and age (<50 years old [C] and ≥ 50 years old [D]). Note: Study undertaken in Vitória, Espírito Santo, Brazil, in 2016. Abbreviations: MS, metabolic syndrome; us-CRP, ultrasensitive C-reactive protein.
Figure 3
Figure 3
Frequency of the number of MS criteria and the percentage of altered us-CRP. Note: Study undertaken in Vitória, Espírito Santo, Brazil, in 2016. Abbreviations: MS, metabolic syndrome; us-CRP, ultrasensitive C-reactive protein.
Figure 4
Figure 4
Frequency of the number of MS criteria and the average us-CRP values stratified by sex. Note: Study undertaken in Vitória, Espírito Santo, Brazil, in 2016. Abbreviations: MS, metabolic syndrome; us-CRP, ultrasensitive C-reactive protein.
Figure 5
Figure 5
Behavior of MS criteria according to altered us-CRP versus normal us-CRP. Notes: (A) Waist circumference; (B) fasting glucose; (C) HDL-c; (D) TAG; (E) SBP; and (F) DBP. Student’s t-test for independent samples was used for A, E, and F. Mann–Whitney U test was used for B, C, and D. Values indicated with “*” are the outliers; P-values shown with “*” are significant; P-values shown without “*” are not significant. Study undertaken in Vitória, Espírito Santo, Brazil, in 2016. Abbreviations: DBP, diastolic blood pressure; HDL-c, high-density lipoprotein cholesterol; MS, metabolic syndrome; SBP, systolic blood pressure; TAG, triglycerides; us-CRP, ultrasensitive C-reactive protein.
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