Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 May 11:5:86.
doi: 10.4103/2277-9175.182217. eCollection 2016.

Nasal colonization in children with community acquired methicillin-resistant Staphylococcus aureus

Fazlollah Davoodabadi  1 , Sina Mobasherizadeh  2 , Kamyar Mostafavizadeh  2 , Hasan Shojaei  1 , Seyed Asghar Havaei  3 , Ali Mehrabi Koushki  4 , Zahra Moghadasizadeh  1 , Mohsen Meidani  1 , Kiana Shirani  5
Affiliations

Nasal colonization in children with community acquired methicillin-resistant Staphylococcus aureus

Fazlollah Davoodabadi et al. Adv Biomed Res. .

Abstract

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a frequent cause of infections. The changing epidemiology of MRSA became evident in the 1990s when CA-MRSA cases were first reported. Nasal carriage of CA-MRSA is associated with an increased risk for development of infections in various populations.

Materials and methods: Anterior nares culture for the presence of methicillin-susceptible Staphylococcus aureus (MSSA) and MRSA was taken from 345 children attending kindergartens, who didn't have any known risk factor for MRSA colonization. Also, children demographic variables were recorded. Identification of SA and community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) with standard microbiological test was performed. Finally, the susceptibility of isolated to various antibiotics determined. The data were analyzed with Whonet 5.6 software.

Results: Of 345 children, 20 children (5.8%) were colonized with CA-MRSA, 86 children (24.9%) with MSSA and 239 cases (69.3%) didn't have SA colonization. The highest rate of MSSA and MRSA colonization was obtained at the age of 6 years. The frequency distribution of SA (MSSA and MRSA) colonization prevalence didn't have any significant differences based on age, gender and the admission time (P > 0.05); but it was significantly different in the urban areas (P < 0.001). The lowest resistance rate of CA-MRSA isolates, with a frequency of 10%, was detected with gentamicin, rifampin, and trimethoprim-sulfamethoxazole.

Conclusions: In summary, CA-MRSA colonization was observed in child care centers remarkably. Therefore, by facing various infections due to SA especially in areas of low socio-economic status, it must be considered. Based on antibiogram test, empirical treatment with rifampin, gentamicin and ciprofloxacin is recommended during CA-MRSA infections.

Keywords: Community-acquired; methicillin-resistant Staphylococcus aureus; methicillin-susceptible Staphylococcus aureus.

PubMed Disclaimer

Figures

Figure 1
Figure 1
The distribution of age and sex
Figure 2
Figure 2
Frequency of Staphylococcus aureus colonization
Figure 3
Figure 3
Frequency of antibiotic-resistant strain of methicillin-resistant Staphylococcus aureus discovered
See this image and copyright information in PMC

References

    1. Cohen J, Powderly WG, Opal SM. 3rd ed. London: Mosby Elsevier Science; 2010. Infectious Diseases.
    1. Davis JP, Fox BC. Hospital and Clinics Community Associated Methicillin Resistant Staphylococcus aureus (CA MRSA) Guidelines for Clinical Management and Control of Transmission PPH 42160, University of Wsconsin, October, 2005
    1. Salmenlinna S, Lyytikäinen O, Vuopio-Varkila J. Community-acquired methicillin-resistant Staphylococcus aureus, Finland. Emerg Infect Dis. 2002;8:602–7. - PMC - PubMed
    1. Fridkin SK, Hageman JC, Morrison M, Sanza LT, Como-Sabetti K, Jernigan JA, et al. Methicillin-resistant Staphylococcus aureus disease in three communities. N Engl J Med. 2005;352:1436–44. - PubMed
    1. Gerald L. 7th ed. London: Churchill Livingstone; 2010. Principles and Practice of Infectious Diseases.