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Case Reports
. 2016 May 25;2(3):206-8.
doi: 10.1016/j.jdcr.2016.03.010. eCollection 2016 May.

Keratoacanthoma centrifugum marginatum: A diagnostic and therapeutic challenge

Nicole Dominiak  1 , Ben Hayes  2 , Julie Swick  3 , Brian Leach  4 , John Maize Sr  5 , Jonathan Ralston  1
Affiliations
Case Reports

Keratoacanthoma centrifugum marginatum: A diagnostic and therapeutic challenge

Nicole Dominiak et al. JAAD Case Rep. .
No abstract available

Keywords: 5-fluorouracil; KA, keratoacanthoma; KCM, keratoacanthoma centrifugum marginatum; dermatopathology; intralesional; keratoacanthoma; keratoacanthoma centrifugum marginatum; trauma.

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Figures

Fig 1
Fig 1
Keratoacanthoma centrifugum marginatum. The lesion began as a single erythematous papule that progressed to an irregular 7.5- × 3.5-cm boggy tumor on the left anterior knee approximately 1 year after localized trauma.
Fig 2
Fig 2
A low-power view of the incisional biopsy with zonal changes from the periphery to the center of the lesion. The outer edge is characterized by pseudoepitheliomatous hyperplasia and a dense mixed inflammatory infiltrate both superficially as well as deep. Centrally, the lesion shows fibrosis and a lack of epidermal hyperplasia. (Hematoxylin-eosin stain; original magnification: ×2.)
Fig 3
Fig 3
A high-power view shows islands of keratinocytes with squamous pearls and minimal atypia underlying pseudoepitheliomatous hyperplasia. (Hematoxylin-eosin stain; original magnification: ×20.)
Fig 4
Fig 4
A high-power view shows the eosinophilic, glassy cytoplasm of the keratinocytes, minimal atypia, and a single mitotic figure near the basal layer. The dermal inflammatory infiltrate is a mixture of lymphocytes, histiocytes, eosinophils, and a few plasma cells. (Hematoxylin-eosin stain; original magnification: ×40.)
Fig 5
Fig 5
Clinical photo shows complete response within weeks of receiving 2 courses of intralesional 5-fluorouracil injections.
See this image and copyright information in PMC

References

    1. Phiske M., Avhad G., Jerajani H.R. “Keratoacanthoma Centrifugum Marginatum at an Unusual Site”. Indian J Dermatol. 2013;58(1):74–76. - PMC - PubMed
    1. V'Ickova-Laskoska M.T., Laskoski D.S. “Keratoacanthoma centrifugum marginatum: a rare atypical variant of keratoacanthoma”. Clin Exp Dermatol. 2007;33:259–261. - PubMed
    1. Mangas C., Bielsa I., Ribera M., Fernandez-Fiqueras M.T., Ferrandiz C. “A Case of Multiple Keratoacanthoma Centrifugum Marginatum”. Dermatol Surg. 2004;30:803–806. - PubMed
    1. Nag F., Biswas P., Singha J., Ghosh A., Trupti S. “Keratoacanthoma Centrifugum Marginatum with Atypical Scar”. Case Rep Dermatol Med. 2012;2012:158. - PMC - PubMed
    1. Miedzinski F., Kozakiewicz J. “Das keratoacanthoma centrifugum eine besandera varietat des keratoacanthomas”. Hautarzt. 1962;13:348–352. - PubMed

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