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Review
. 2016 Jun 6;17(6):846.
doi: 10.3390/ijms17060846.

Human Saliva Collection Devices for Proteomics: An Update

Zohaib Khurshid  1 , Sana Zohaib  2 , Shariq Najeeb  3 , Muhammad Sohail Zafar  4 , Paul D Slowey  5 , Khalid Almas  6
Affiliations
Review

Human Saliva Collection Devices for Proteomics: An Update

Zohaib Khurshid et al. Int J Mol Sci. .

Abstract

There has been a rapid growth in the interest and adaptation of saliva as a diagnostic specimen over the last decade, and in the last few years in particular, there have been major developments involving the application of saliva as a clinically relevant specimen. Saliva provides a "window" into the oral and systemic health of an individual, and like other bodily fluids, saliva can be analyzed and studied to diagnose diseases. With the advent of new, more sensitive technologies to detect smaller concentrations of analytes in saliva relative to blood levels, there have been a number of critical developments in the field that we will describe. In particular, recent advances in standardized saliva collection devices that were not available three to four years ago, have made it easy for safe, simple, and non-invasive collection of samples to be carried out from patients. With the availability of these new technologies, we believe that in the next decade salivary proteomics will make it possible to predict and diagnose oral as well as systemic diseases, cancer, and infectious diseases, among others. The aim of this article is to review recent developments and advances in the area of saliva specimen collection devices and applications that will advance the field of proteomics.

Keywords: omics; proteomics; saliva collection devices; salivaomics; salivary biomarkers.

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Figures

Figure 1
Figure 1
Illustration of whole mouth saliva representing the properties of saliva.
Figure 2
Figure 2
A selection of different saliva collection devices used in medical and dental research. (A) Salivette® (Sarstedt); (B) Quantisal ® (Immunalysis); (C) SCS® (Greiner-BioOne).
Figure 3
Figure 3
Saliva Collection Device manufactured by Oasis Diagnostics® Corporation; (A) Super•SAL™ and (B) Versi•SAL®.
See this image and copyright information in PMC

References

    1. Su S.-B., Chuen T., Poon W., Thongboonkerd V. Human Body Fluid. BioMed Res. Int. 2013;2013:2–4. doi: 10.1155/2013/918793. - DOI - PMC - PubMed
    1. Gstaiger M., Aebersold R. Applying mass spectrometry-based proteomics to genetics, genomics and network biology. Nat. Rev. Genet. 2009;10:617–627. doi: 10.1038/nrg2633. - DOI - PubMed
    1. Horgan R., Kenny L. “Omic”technologies: Genomics, transcriptomics, proteomics and metabolomics. Obstet. Gynaecol. 2011;13:189–195. doi: 10.1576/toag.13.3.189.27672. - DOI
    1. Ai J., Smith B., Wong D.T. Saliva ontology: An ontology-based framework for a Salivaomics Knowledge Base. BMC Bioinform. 2010;11 doi: 10.1186/1471-2105-11-302. - DOI - PMC - PubMed
    1. Viet C.T., Schmidt B.L. Methylation array analysis of preoperative and postoperative saliva DNA in oral cancer patients. Cancer Epidemiol. Biomark. Prev. 2008;17:3603–3611. doi: 10.1158/1055-9965.EPI-08-0507. - DOI - PubMed