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. 2016 Sep;129(2):201-9.
doi: 10.1007/s11060-016-2168-z. Epub 2016 Jun 9.

Inhibition of pentraxin 3 in glioma cells impairs proliferation and invasion in vitro and in vivo

Jai-Nien Tung  1 , Chung-Po Ko  1   2 , Shun-Fa Yang  2 , Chun-Wen Cheng  3 , Pei-Ni Chen  3 , Chia-Yu Chang  3 , Chia-Liang Lin  3 , Te-Fang Yang  3 , Yi-Hsien Hsieh  4   5 , Kun-Chung Chen  6   7
Affiliations

Inhibition of pentraxin 3 in glioma cells impairs proliferation and invasion in vitro and in vivo

Jai-Nien Tung et al. J Neurooncol. 2016 Sep.

Abstract

Pentraxin 3 (PTX3) is an inflammatory molecule that is involved in immune responses, inflammation, and cancer. Recent evidence suggests that PTX3 plays a critical role in tumor progression; however, its impact on the biological function of gliomas remains unknown. In the present study, immunohistochemical staining showed that patients with high-grade gliomas exhibited increased expression levels of PTX3 compared to those with low-grade gliomas (P < 0.001). Furthermore, knockdown of PTX3 in GBM8401 cells inhibits proliferation, increases p21 protein levels, and decreases cyclin D1 protein levels, resulting in cell cycle arrest at the G0/G1 phase. In addition, knockdown of PTX3 significantly decreases GBM8401 cell migration and invasion through the downregulation of matrix metalloproteinase-1 and -2 (MMP-1 and MMP-2) expression. In a GBM8401 xenograft animal model, PTX3 knockdown decreases tumor growth in vivo. In conclusion, PTX3 plays an important role in glioma cell proliferation and invasion, and may thus serve as a novel potential therapeutic target in the treatment of gliomas.

Keywords: Gliomas; Invasion; Migration; Pentraxin 3; Proliferation.

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