Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Mar;28(85):141-7.

Evaluation of Post Laryngectomy Pharyngocutaneous Fistula risk Factors

Sophia Nitassi  1 , Jihane Belayachi  2 , Mohammed Chihab  1 , Ilham Rkain  1 , Jalila Benayad  1 , Mohammed Anas Benbouzid  1 , Abdelillah Oujilal  1 , Leila Essakalli  1
Affiliations

Evaluation of Post Laryngectomy Pharyngocutaneous Fistula risk Factors

Sophia Nitassi et al. Iran J Otorhinolaryngol. 2016 Mar.

Abstract

Introduction: Pharyngocutaneous fistula (PCF) is the most common complication after total laryngectomy. Its incidence is extremely variable, with values ranging from 3% and 65%. The management of this problem considerably increases the length and the cost of hospitalization. The aim of this study is to analyze the incidence, predisposing factors, and outcome of PCF in patients undergoing total laryngectomy in a Moroccan teaching hospital in Rabat, Morocco.

Materials and methods: This study is a retrospective study including 136 patients who underwent total laryngectomy for squamous cell carcinoma of the larynx in our institution, between January 2006 and December 2013. Socio-demographical, biological, surgical, and outcome data were included. Risk factors were analyzed for association with PCF formation.

Results: The overall PCF rate was 27.8%. The mean age was 58 (32-82 years). Univariate analysis showed age (P= 0,028), hemoglobin (P=0,026), and previous tracheotomy (P=0,028) to be associated with the onset of PCF. However, multivariate analysis revealed that previous tracheotomy (P=0,028) and low level of preoperative hemoglobin (P=0,026) were highly associated with the occurrence of PCF.

Conclusion: This is an original work performed in an African country with a large serie. Our findings suggest that age, previous tracheotomy, and low level of haemoglobin are risk factors for PCF onset after total laryngectomy in T4 squamous cell carcinoma.

Keywords: Fistula; Incidence; Pharyngeal; Risk Factor; Total laryngectomy..

PubMed Disclaimer

References

    1. Rosenthal Di, Mohamed As, Weber Rs, Garden As, Sevak Pr, Kies Ms, et al. Long-term outcomes after surgical or nonsurgical initial therapy for patients with T4 squamous cell carcinoma of the larynx: A 3-decade survey. Cancer. 2015;121(10):1608–19. - PMC - PubMed
    1. SATOT Treatment of laryngeal cancer Gan No Rinsho. 1985;31(12):1581–9. - PubMed
    1. Mäkitie Aa, Niemensivu R, Hero M, Keski-Säntti H, Bäck L, Kajanti M, et al. Pharyngocutaneous fistula following total laryngectomy: a single institution's 10-year experience. Eur Arch Otorhinolaryngol. 2006;263 (12):1127–30. - PubMed
    1. Palomar-Asenjo V, Sarroca Capell E, Tobías Gómez S, Pérez Hernández I, Palomar-García V. Pharyngocutaneous Fistula Following Total Laryngectomy. A Case-Control Study of Risk : Factors Implicated in its Onset. Acta Otorrinolaringol Esp. 2008;59(10):480–4. - PubMed
    1. Cecattoa Sb, Monteiro Soaresa M, Henriquesa T, Monteirob E, Ferreira Pinto Mourac CI. Predictive factors for the postlaryngectomy pharyngocutaneous fistula development: systematic review. Braz J Otorhinolaryngol. 2014;80(2):167–77. - PMC - PubMed

LinkOut - more resources