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. 2016 Jan 12;4(1):E13-9.
doi: 10.9778/cmajo.20150067. eCollection 2016 Jan-Mar.

Postpartum domperidone use in British Columbia: a retrospective cohort study

Kate Smolina  1 , Steven G Morgan  1 , Gillian E Hanley  1 , Tim F Oberlander  1 , Barbara Mintzes  1
Affiliations

Postpartum domperidone use in British Columbia: a retrospective cohort study

Kate Smolina et al. CMAJ Open. .

Abstract

Background: Domperidone is commonly used off-label to stimulate milk production in mothers who have low milk supply. The aim of this study was to describe trends, patterns and determinants of postpartum domperidone use.

Methods: This is a retrospective, population-based study involving all women with a live birth between Jan. 1, 2002, and Dec. 31, 2011, in the province of British Columbia. We examined administrative data sets containing person-specific information on filled prescriptions and use of medical services, and we used logistic regression to examine associations between domperidone use and maternal characteristics.

Results: The study population consisted of 225 532 women with 320 351 live births. The prevalence of postpartum domperidone use more than doubled between 2002 and 2011. In 2011, 1 in 3 women with a preterm birth and 1 in 5 women with a full-term birth were prescribed domperidone in the first 6 months postpartum. Women who were older, had a higher body mass index, had a chronic disease, were first-time mothers, delivered more than 1 baby (multiple pregnancy), had a preterm birth or had a cesarian delivery were more likely to fill a postpartum domperidone prescription.

Interpretation: We found an increase in postpartum domperidone use over a 10-year period. More research is needed on maternal and infant health outcomes.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Domperidone use in the first 6 months postpartum among women in British Columbia with live births.
Figure 2
Figure 2
Distribution of daily doses per dispensed domperidone prescription in 2002 and 2011.
Figure 3
Figure 3
Duration of domperidone therapy during the first 6 months postpartum in 2002 and 2011.
See this image and copyright information in PMC

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