Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Observational Study
. 2016 Jun;95(23):e3856.
doi: 10.1097/MD.0000000000003856.

The association between human papillomavirus infection and female lung cancer: A population-based cohort study

Frank Cheau-Feng Lin  1 , Jing-Yang Huang, Stella Ching-Shao Tsai, Oswald Ndi Nfor, Ming-Chih Chou, Ming-Fang Wu, Chun-Te Lee, Cheng-Feng Jan, Yung-Po Liaw
Affiliations
Observational Study

The association between human papillomavirus infection and female lung cancer: A population-based cohort study

Frank Cheau-Feng Lin et al. Medicine (Baltimore). 2016 Jun.

Erratum in

  • Erratum: Medicine, Volume 95, Issue 23: Erratum.
    [No authors listed] [No authors listed] Medicine (Baltimore). 2016 Jul 18;95(28):e0916. doi: 10.1097/01.md.0000489580.04709.16. eCollection 2016 Jul. Medicine (Baltimore). 2016. PMID: 31265603 Free PMC article.

Abstract

Lung cancer is the leading cause of cancer deaths among Taiwanese women. Human papillomavirus (HPV) has been detected in lung cancer tissues. The aim of this study was to investigate the association between HPV infection and lung cancer among the Taiwanese women. The analytical data were collected from the longitudinal health insurance databases (LHID 2005 and 2010) of the National Health Insurance Research Database (NHIRD). The study participants were 30 years and older and included 24,162 individuals who were identified with HPV infection from 2001 to 2004 and 1,026,986 uninfected individuals. Lung cancer incidence among infected and uninfected individuals was compared using the univariate and multivariate regression models. Among the total participants, 24,162 individuals were diagnosed with HPV. After adjusting for age, gender, low income, residential area, and comorbidity, the risk of lung cancer was higher in women (hazard ratio [HR] 1.263, 95% CI 1.015-1.571), while all cancer risks were high in both men and women with corresponding hazard ratios (HR) of 1.161 (95% CI 1.083-1.245) and HR 1.240 (95% CI 1.154-1.331), respectively. This study showed a significant increase in lung cancer risk among Taiwanese women who were exposed to HPV infection.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of the study population.
Figure 2
Figure 2
Kaplan–Meier curve of the cumulative incidence of lung cancer among infected and uninfected male participants.
Figure 3
Figure 3
Kaplan–Meier curve of the cumulative incidence of cancer among infected and uninfected female participants.
See this image and copyright information in PMC

References

    1. 2010 Statistics of Causes of Death. 2011; Available at: http://www.doh.gov.tw/ufile/doc/2010-statistics%20of%20cause%20of%20deat... Accessed April 26, 2012.
    1. Spano J-P, Busson P, Atlan D, et al. Nasopharyngeal carcinomas: an update. Eur J Cancer 2003; 39:2121–2135. - PubMed
    1. Bosch F, Lorincz A, Munoz N, et al. The causal relation between human papillomavirus and cervical cancer. J Clin Pathol 2002; 55:244–265. - PMC - PubMed
    1. Anorlu RI. What is the significance of the HPV epidemic? Can J Urol 2008; 15:3860–3865. - PubMed
    1. zur Hausen H. Human papillomavirus & cervical cancer. Indian J Med Res 2009; 130:209. - PubMed

Publication types