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Observational Study
. 2016 Jun;95(23):e3886.
doi: 10.1097/MD.0000000000003886.

Therapeutic bronchoscopic interventions for malignant airway obstruction: A retrospective study from experience on 547 patients

Levent Dalar  1 , Cengiz Özdemir, Yasin Abul, Levent Karasulu, Sinem Nedime Sökücü, Ayşegül Akbaş, Sedat Altn
Affiliations
Observational Study

Therapeutic bronchoscopic interventions for malignant airway obstruction: A retrospective study from experience on 547 patients

Levent Dalar et al. Medicine (Baltimore). 2016 Jun.

Erratum in

  • Erratum: Medicine, Volume 95, Issue 23: Erratum.
    [No authors listed] [No authors listed] Medicine (Baltimore). 2016 Jul 18;95(28):e0916. doi: 10.1097/01.md.0000489580.04709.16. eCollection 2016 Jul. Medicine (Baltimore). 2016. PMID: 31265603 Free PMC article.

Abstract

There is no definitive consensus about the factors affecting the choice of interventional bronchoscopy in the management of malignant airway obstruction. The present study defines the choice of the interventional bronchoscopic modality and analyzes the factors influencing survival in patients with malignant central airway obstruction. Totally, over 7 years, 802 interventional rigid bronchoscopic procedures were applied in 547 patients having malignant airway obstruction. There was a significant association between the type of stent and the site of the lesion in the present study. Patients with tracheal involvement and/or involvement of the main bronchi had the worst prognosis. The sites of the lesion and endobronchial treatment modality were independent predictors of survival in the present study. The selection of different types of airway stents can be considered on the base of site of the lesion. Survival can be estimated based on the site of the lesion and endobronchial brochoscopic modality used.

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Conflict of interest statement

The authors have no funding and conflicts of interest to disclose.

Figures

Figure 1
Figure 1
(A) A 57-year-old patient with squamous cell carcinoma type and lobulated mass lesion located in midportion of the trachea causing 65% of the lumen obstruction before the endobronchial treatment. (B) Tumor was coaugulated with diode laser and obstruction was relieved totally by rigid bronchoscopic intervention. Scabbard trachea was also seen and noticed easily after the endobronchial treatment.
Figure 2
Figure 2
(A) A 54-year-old patient with internal and external tracheal tumoral compression who presented with respiratory insufficiency and tracheal lumen was obstructed >90%. (B) Early findings seen after dilatation of the distal trachea by rigid bronchoscopy. (C) Late findings seen after dilatation of the distal trachea by rigid bronchoscopy showing decreased tracheal osbtruction. (D) Placement of Dumon Y stent that was located on carina.
Figure 3
Figure 3
Type of malignancy causing central airway obstruction as a factor affecting survival of the study population represented as the Kaplan–Meier curve (P < 0.01).
Figure 4
Figure 4
Site of the lesion as a factor affecting survival of the study population represented as the Kaplan–Meier curve (P < 0.01).
Figure 5
Figure 5
Type of endobronchial treatment modality as a factor affecting survival of the study population represented as the Kaplan–Meier curve (P = 0.01).
Figure 6
Figure 6
Cumulative survival of study cohort during 365 days (1 year) period.
See this image and copyright information in PMC

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