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. 2016 Jul:59:49-51.
doi: 10.1016/j.bcmd.2016.04.001. Epub 2016 Apr 13.

Variants of ZBTB7A (LRF) and its β-globin gene cluster binding motifs in sickle cell anemia

Elmutaz M Shaikho  1 , Alawi H Habara  1 , Abdulrahman Alsultan  2 , A M Al-Rubaish  3 , Fahad Al-Muhanna  3 , Z Naserullah  4 , A Alsuliman  5 , Hatem O Qutub  6 , P K Patra  7 , Paola Sebastiani  8 , Kristin Baltrusaitis  8 , John J Farrell  1 , Zhihua Jiang  1 , Hong-Yuan Luo  1 , David H K Chui  1 , Amein K Al-Ali  9 , Martin H Steinberg  10
Affiliations

Variants of ZBTB7A (LRF) and its β-globin gene cluster binding motifs in sickle cell anemia

Elmutaz M Shaikho et al. Blood Cells Mol Dis. 2016 Jul.
No abstract available

Keywords: Arab-Indian haplotype; Fetal hemoglobin; HbF; LRF; SNPs.

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Conflict of interest statement

Conflict-of-interest disclosure:The authors declare no competing interests.

Figures

Figure 1.
Figure 1.
Approximate locations of the putative binding motifs for ZBTB7A (first track) that contained polymorphisms (shown above track) and were located between OR51V1 in the 5’ olfactory receptor gene cluster and OR51B4 in the 3’ olfactory gene cluster flanking the HBBlike genes and its locus control region (LCR) on chromosome 11p15.5. SNPs in the binding motifs are shown (arrows) with their major/alternative alleles. ChIP-seq data (tracks 2 and 3) is taken from(7) along with the relative locations of globin genes and the LCR (track 4). Extensive homology between HBG2 and HBG1 makes mapping to these regions difficult and ChIP-seq data only showed uniquely-mapped binding in HBG1 (track 3)
See this image and copyright information in PMC

References

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