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. 2016 Sep;138(3):893-895.e5.
doi: 10.1016/j.jaci.2016.03.040. Epub 2016 May 6.

The quest for autoreactive antibodies in nasal polyps

Els De Schryver  1 , Lien Calus  1 , Henryk Bonte  1 , De Ruyck Natalie  2 , Hannah Gould  3 , Erin Donovan  4 , Dirk Elewaut  5 , Rudolf Valenta  6 , Irene Mittermann  6 , Jan Gutermuth  7 , Tanja Seher  8 , Robert P Schleimer  9 , Bruce K Tan  9 , Lara Derycke  1 , Thibaut Van Zele  1 , Claus Bachert  10 , Philippe Gevaert  11
Affiliations

The quest for autoreactive antibodies in nasal polyps

Els De Schryver et al. J Allergy Clin Immunol. 2016 Sep.
No abstract available

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Conflict of interest statement

Disclosure of potential conflict of interest: E. de Schryver declares being employed at Ghent University Hospital. The rest of the authors declare that they have no relevant conflicts of interest.

Figures

FIG 1
FIG 1
The detection of local and serum anti-dsDNA IgG. Data are expressed in Box-Whisker plots presenting the results of local and systemic anti-dsDNA IgG in patients with nasal polyps and healthy subjects. Significance (P) values after Mann-Whitney U test are represented by * when P < .05.
FIG 2
FIG 2
The detection of autoreactive IgE to the human epithelial cell line A431 (A), of local anti-IgE IgG (B) and of autoreactive IgE to skin and lung epithelium (C). A, Positive (atopic dermatitis [AD]) and negative controls are shown in this western blot. Molecular weights (kDa) are indicated at the left and right margins. B, Each subject’s anti-IgE IgG value is presented in the bar graph. The 75th percentile (8.991 ng/mL) is represented by the dotted line. C, Median values, 25th and 75th percentiles are presented by Box-Whisker plots.
See this image and copyright information in PMC

References

    1. Van Zele T, Gevaert P, Holtappels G, van Cauwenberge P, Bachert C. Local immunoglobulin production in nasal polyposis is modulated by superantigens. Clin Exp Allergy. 2007;37:1840–7. - PubMed
    1. Hulse KE, Norton JE, Suh L, Zhong Q, Mahdavinia M, Simon P, et al. Chronic rhinosinusitis with nasal polyps is characterized by B-cell inflammation and EBV-induced protein 2 expression. J Allergy Clin Immunol. 2013;131:1075–83. 1083.e1–7. - PMC - PubMed
    1. Gevaert P, Nouri-Aria KT, Wu H, Harper CE, Takhar P, Fear DJ, et al. Local receptor revision and class switching to IgE in chronic rhinosinusitis with nasal polyps. Allergy. 2013;68:55–63. - PubMed
    1. Bachert C, Zhang N, van Zele T, Gevaert P, Patou J, van Cauwenberge P. Staphylococcus aureus enterotoxins as immune stimulants in chronic rhinosinusitis. Clin Allergy Immunol. 2007;20:163–75. - PubMed
    1. Zambetti G, Ciofalo A, Soldo P, Fusconi M, Romeo R, Greco A, et al. Autologous serum skin test reactivity and basophil histamine release test in patients with nasal polyposis: preliminary results. Int J Immunopathol Pharmacol. 2010;23:641–7. - PubMed

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