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Editorial
. 2016 Jun 10;118(12):1858-60.
doi: 10.1161/CIRCRESAHA.116.308978.

Can Endothelial Injury Provide the Passage to Explain the Vascular Effects of Proton Pump Inhibitors?

Surovi Hazarika  1 , Brian H Annex  2
Affiliations
Editorial

Can Endothelial Injury Provide the Passage to Explain the Vascular Effects of Proton Pump Inhibitors?

Surovi Hazarika et al. Circ Res. .
No abstract available

Keywords: Editorial; endothelial dysfunction; proton pump inhibitors; vascular function.

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Figures

Figure
Figure. Summary of predicted pathophysiology leading to atherosclerotic vascular diseases that can account as the potential unifying factor in the clinical associations noted with long-term proton pump inhibitor (PPI) use
It is important to note the limitation that there are gaps in translating conclusions from observations noted in one type of endothelial cells (EC) in culture to in vivo vascular dysfunction. NO indicates nitric oxide.
See this image and copyright information in PMC

Comment on

  • Proton Pump Inhibitors Accelerate Endothelial Senescence.
    Yepuri G, Sukhovershin R, Nazari-Shafti TZ, Petrascheck M, Ghebre YT, Cooke JP. Yepuri G, et al. Circ Res. 2016 Jun 10;118(12):e36-42. doi: 10.1161/CIRCRESAHA.116.308807. Epub 2016 May 10. Circ Res. 2016. PMID: 27166251 Free PMC article.

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