SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals

Pablo Carbonell¹, Andrew Currin¹, Mark Dunstan¹, Donal Fellows¹, Adrian Jervis¹, Nicholas J W Rattray¹, Christopher J Robinson¹, Neil Swainston¹, Maria Vinaixa¹, Alan Williams¹, Cunyu Yan¹, Perdita Barran², Rainer Breitling², George Guo-Qiang Chen², Jean-Loup Faulon², Carole Goble³, Royston Goodacre², Douglas B Kell², Rosalind Le Feuvre⁴, Jason Micklefield², Nigel S Scrutton⁵, Philip Shapira⁶, Eriko Takano⁷, Nicholas J Turner⁷

Affiliations

¹ BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K.
² BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM Platform/Theme Lead, School of Chemistry, The University of Manchester, Manchester, U.K.
³ BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM Data Lead, School of Computer Science, The University of Manchester, Manchester, U.K.
⁴ BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM, Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K.
⁵ BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM Platform/Theme Lead, School of Chemistry, The University of Manchester, Manchester, U.K. SYNBIOCHEM, The University of Manchester, Manchester, U.K. nigel.scrutton@manchester.ac.uk.
⁶ BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM Responsible Research Innovation Lead, Alliance Manchester Business School, The University of Manchester, Manchester, U.K.
⁷ BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM Platform/Theme Lead, School of Chemistry, The University of Manchester, Manchester, U.K. SYNBIOCHEM, The University of Manchester, Manchester, U.K.

PMID: 27284023
PMCID: PMC4900749
DOI: 10.1042/BST20160009

SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals

Pablo Carbonell et al. Biochem Soc Trans. 2016.

. 2016 Jun 15;44(3):675-7.

doi: 10.1042/BST20160009.

Authors

Affiliations

¹ BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K.
² BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM Platform/Theme Lead, School of Chemistry, The University of Manchester, Manchester, U.K.
³ BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM Data Lead, School of Computer Science, The University of Manchester, Manchester, U.K.
⁴ BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM, Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K.
⁵ BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM Platform/Theme Lead, School of Chemistry, The University of Manchester, Manchester, U.K. SYNBIOCHEM, The University of Manchester, Manchester, U.K. nigel.scrutton@manchester.ac.uk.
⁶ BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM Responsible Research Innovation Lead, Alliance Manchester Business School, The University of Manchester, Manchester, U.K.
⁷ BBSRC/EPSRC Synthetic Biology Research Centre for Fine and Speciality Chemicals (SYNBIOCHEM), Manchester Institute of Biotechnology, The University of Manchester, Manchester, U.K. SYNBIOCHEM Platform/Theme Lead, School of Chemistry, The University of Manchester, Manchester, U.K. SYNBIOCHEM, The University of Manchester, Manchester, U.K.

PMID: 27284023
PMCID: PMC4900749
DOI: 10.1042/BST20160009

Abstract

The Manchester Synthetic Biology Research Centre (SYNBIOCHEM) is a foundry for the biosynthesis and sustainable production of fine and speciality chemicals. The Centre's integrated technology platforms provide a unique capability to facilitate predictable engineering of microbial bio-factories for chemicals production. An overview of these capabilities is described.

Keywords: biocatalysis; fine chemicals; metabolic engineering; synthetic biology; systems biology.

PubMed Disclaimer

Figures

**Figure 1. Schematic of the SYNBIOCHEM synthetic biology foundry**
Schematic of the foundry concept established in SYNBIOCHEM that enables iterative Design, Build and Test workflows for the engineering of new biological parts (e.g. enzymes and regulatory components), devices (e.g. pathways and cellular compartments) and systems (microbial chassis and processes).

See this image and copyright information in PMC

References

1. Li Y., Shapira P. Synthetic biology: reshaping the future? PLOS Synbio. Blog. 2016 26 Jan. https://t.co/v91JxkPFWf.
1. McLean K.J., Hans M., Meijrink B., van Scheppingen W.B., Vollebregt A., Tee K.L., van der Laan J.M., Leys D., Munro A.W., van den Berg M.A. Single-step fermentative production of the cholesterol-lowering drug pravastatin via reprogramming of Penicillium chrysogenum. Proc. Natl. Acad. Sci. U.S.A. 2015;112:2847–2852. doi: 10.1073/pnas.1419028112. - DOI - PMC - PubMed
1. Toogood H.S., Cheallaigh A.N., Tait S., Mansell D.J., Jervis A., Lygidakis A., Humphreys L., Takano E., Gardiner J.M., Scrutton N.S. Enzymatic menthol production: one-pot approach using engineered Escherichia coli. ACS Synth. Biol. 2015;4:1112–1123. doi: 10.1021/acssynbio.5b00092. - DOI - PubMed
1. Menon N., Pásztor A., Menon B.R.K., Kallio P., Fisher K., Akhtar M.K., Leys D., Jones P.R., Scrutton N.S. A microbial platform for renewable propane synthesis based on a fermentative butanol pathway. Biotechnol. Biofuels. 2015;8:61. doi: 10.1186/s13068-015-0231-1. - DOI - PMC - PubMed
1. Wu M.C., Lowe P.T., Robinson C.J., Vincent H.A., Dixon N., Leigh J., Micklefield J. Rational re-engineering of a transcriptional silencing PreQ1 riboswitch. J. Am. Chem. Soc. 2015;137:9015–9021. doi: 10.1021/jacs.5b03405. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals

Affiliations

SYNBIOCHEM-a SynBio foundry for the biosynthesis and sustainable production of fine and speciality chemicals

Authors

Affiliations

Abstract

Figures

References

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources