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. 2016 Jun;4(6):741-745.
doi: 10.3892/br.2016.644. Epub 2016 Mar 31.

A meta-analysis of the association between Behçet's disease and MICA-A6

Feiran Wei  1 , Y U Zhang  1 , Wei Li  2
Affiliations

A meta-analysis of the association between Behçet's disease and MICA-A6

Feiran Wei et al. Biomed Rep. 2016 Jun.

Abstract

Behçet's disease (BD) is a multi-system inflammatory condition with unknown cause, characterized by a triple-symptom complex of recurrent oral aphthous ulcers, genital ulcers, and uveitis and skin lesions. It predominantly affects people living around the Mediterranean basin and in Japan. The effects of the major histocompatibility complex class I chain related gene A (MICA) A6 allele on susceptibility to Behçet's disease (BD) have been reported previously, however, their results have been unreliable. The present study aimed to determine whether an association between the MICA-A6 allele and BD susceptibility exists. A total of 12 case-control studies, examining the association between MICA-A6 and BD and involving 752 cases and 1,175 controls were included in the present meta-analysis. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The results of meta-analysis revealed that the frequency of the MICA-A6 allele in the case group was significantly higher than those in the control groups (P<0.001, OR=2.43, 95% CI: 1.99-2.97). Sub-group analysis by ethnicity indicated that the association between of MICA-A6 gene to BD remained in Asian populations (5 cases and 731 controls) and Caucasian populations (242 cases and 444 controls) with OR=2.65, 95% CI: 2.07-3.38 and OR=2.23, 95% CI: 1.37-3.62, respectively. These findings demonstrate that MICA-A6 gene is associated with susceptibility to BD. The MICA-A6 gene may serve as an early diagnostic marker for BD in the future.

Keywords: BD; MICA-A6; meta-analysis.

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Figures

Figure 1.
Figure 1.
Flow diagram of study selection.
Figure 2.
Figure 2.
Association between MICA-A6 gene and Behçet's disease. OR, odds ratio; CI, confidence interval.
Figure 3.
Figure 3.
Association between the MICA-A6 gene and Behçet's disease by ethnicity. OR, odds ratio; CI, confidence interval.
Figure 4.
Figure 4.
Begg's funnel plot for publication bias analysis of the MICA-A6 gene.
See this image and copyright information in PMC

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