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Comment
. 2016 Aug;23(8):1267-8.
doi: 10.1038/cdd.2016.55. Epub 2016 Jun 10.

Non-canonical autophagy LAPs lupus

A K Simon  1   2 , A J Clarke  1
Affiliations
Comment

Non-canonical autophagy LAPs lupus

A K Simon et al. Cell Death Differ. 2016 Aug.
No abstract available

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Figures

Figure 1
Figure 1
Non-canonical autophagy in the clearance of dead cells. LC3-associated phagocytosis (LAP) is the process by which phagosomes become decorated with LC3 and are subsequently trafficked to the lysosome for degradation. LAP uses a subset of the canonical autophagy machinery, but notably does not need the ULK1 pre-initiation complex, and again, distinct from canonical autophagy, requires Rubicon and Nox2. Following ingestion, dying cells are rapidly degraded and do not induce an autoimmune response. However, when components of the LAP pathway are genetically deleted, although dying cells are engulfed normally they are not degraded and hence the nuclear material escapes and leads to an immune response. Consequently, a systemic inflammatory disease resembling lupus develops
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References

    1. Martinez J et al. Nature 2016; 533: 115–119. - PMC - PubMed
    1. Rhodes B et al. Ann Rheum Dis 2012; 71: 2028–2034. - PMC - PubMed
    1. Green DR, Oguin TH, Martinez J. Cell Death Differ 2016; 23: 915–926. - PMC - PubMed
    1. Bentham J et al. Nat Genet 2015; 47: 1457–1464. - PMC - PubMed
    1. Martinez J et al. Proc Natl Acad Sci USA 2011; 108: 17396–17401. - PMC - PubMed

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