Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jun;5(2):139-53.
doi: 10.1007/s40121-016-0112-3. Epub 2016 Jun 10.

In Vitro Activity of Oral Antimicrobial Agents against Pathogens Associated with Community-Acquired Upper Respiratory Tract and Urinary Tract Infections: A Five Country Surveillance Study

Douglas J Biedenbach  1 , Robert E Badal  2 , Ming-Yi Huang  3 , Mary Motyl  3 , Puneet K Singhal  3 , Roman S Kozlov  4 , Arthur Dessi Roman  5 , Stephen Marcella  3
Affiliations

In Vitro Activity of Oral Antimicrobial Agents against Pathogens Associated with Community-Acquired Upper Respiratory Tract and Urinary Tract Infections: A Five Country Surveillance Study

Douglas J Biedenbach et al. Infect Dis Ther. 2016 Jun.

Erratum in

Abstract

Introduction: Bacterial infections that cause community-acquired urinary tract infections (CA-UTI) and upper respiratory tract infections (CA-URTI) are most frequently treated empirically. However, an increase in antimicrobial resistance has become a problem when treating outpatients.

Methods: This study determined the in vitro activities of oral antibiotics among 1501 pathogens from outpatients with CA-UTI and CA-URTI in medical centers during 2012 and 2013 from Argentina, Mexico, Venezuela, Russia, and the Philippines. Minimal inhibitory concentrations (MICs) were determined using broth microdilution and susceptibility defined by Clinical Laboratory Standards Institute (CLSI) and European Committee for Antimicrobial Susceptibility Testing (EUCAST) criteria.

Results: Ceftibuten (MIC50, ≤0.25 mg/L) was more potent in vitro compared to other β-lactams against Enterobacteriaceae from CA-UTI. Susceptibility to fluoroquinolones using CLSI criteria varied: Argentina and Mexico (50%), the Philippines (60%), Venezuela (70%), and Russia (80%). Fosfomycin susceptibility was >90% against Enterobacteriaceae in each country. Susceptibility among Enterobacteriaceae to trimethoprim-sulfamethoxazole was 30.6-75.6% and nitrofurantoin susceptibility also varied among the countries and was higher when EUCAST breakpoints were applied (65->90%) compared to CLSI (52-84%). All Haemophilus influenzae isolates from CA-URTI were susceptible to ceftibuten, cefixime, cefpodoxime, and cefuroxime using CLSI breakpoint criteria. EUCAST criteria produced intermediate and resistant MIC values for these oral cephalosporins. Country-specific susceptibility variation for fluoroquinolones, macrolides, and trimethoprim-sulfamethoxazole was observed among Streptococcus pneumoniae and Streptococcus pyogenes from CA-URTI.

Conclusion: This study demonstrated that antimicrobial susceptibility patterns varied in the five countries investigated among pathogens from CA-UTI and CA-URTI.

Funding: Merck & Co. Inc., Kenilworth, New Jersey, USA.

Keywords: Community-acquired UTI and RTI; Oral antibiotics; Prescribing practices; Resistance.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Bantar C, Curcio D, Jasovich A, et al. Updated acute community-acquired pneumonia in adults: Guidelines for initial antimicrobial therapy based on local evidence from the South American Working Group (ConsenSur II) Rev Chilena Infectol. 2010;27(Suppl 1):S9–S38. - PubMed
    1. Bours PH, Polak R, Hoepelman AI, Delgado E, Jarquin A, Matute AJ. Increasing resistance in community-acquired urinary tract infections in Latin America, five years after the implementation of national therapeutic guidelines. Int J Infect Dis. 2010;14:770–774. doi: 10.1016/j.ijid.2010.02.2264. - DOI - PubMed
    1. Christiaens T, De Backer D, Burgers J, Baerheim A. Guidelines, evidence, and cultural factors: comparison of four European guidelines on uncomplicated cystitis. Scan J Prim Health Care. 2014;22:141–145. doi: 10.1080/02813430410006521. - DOI - PubMed
    1. Llor C, Rabanaque G, Lopez A, Cots JM. The adherence of GPs to guidelines for the diagnosis and treatment of lower urinary tract infections in women is poor. Fam Pract. 2011;28:294–299. doi: 10.1093/fampra/cmq107. - DOI - PubMed
    1. Rogue F, Soares S, Breitenfeld L, Figueiras A, Herdeiro MT. Influence of community parmacists’ attitudes on antibiotic dispensing behaviour: a cross-sectional study in Portugal. Clin Ther. 2014;37:168–177. doi: 10.1016/j.clinthera.2014.11.006. - DOI - PubMed

LinkOut - more resources