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Case Reports
. 2016 Jun 11:17:395-7.
doi: 10.12659/ajcr.897900.

Benign Hydronephrosis and Elevated of Serum Levels of Carbohydrate Antigen CA 19-9: A Case Report

Branka Filipovic  1 , Nikola Milinić  1 , Jasna Gacic  2 , Olivera Markovic  3 , Aleksandra Djokovic  4 , Branislav Filipovic  5
Affiliations
Case Reports

Benign Hydronephrosis and Elevated of Serum Levels of Carbohydrate Antigen CA 19-9: A Case Report

Branka Filipovic et al. Am J Case Rep. .

Abstract

Background: Carbohydrate tumor-associated antigen (CA 19-9) has been shown to be upregulated in other malignant tumors including gastric, ovarian, hepatocellular, and colorectal carcinoma as well as benign diseases of the biliary track such as pancreatitis, cholangitis, and choledocholithiasis. According to the available literature, in several cases of benign hydronephrosis and in a few cases of benign renal diseases, elevated CA 19-9 has been noted.

Case report: A 58-year-old Caucasian male patient was admitted in our clinic with complaints about blunt abdominal pain in the past two-month period localized in the right lumbar region and irradiating into the right inguinal area, constipation, abdominal bloating, and intermittent hematuria. The concentration of serum CA 19-9 was 3500 U/mL. Urine cytology provided no signs of abnormality. Intravenous urography visualized right-sided pyelon and ureter duplex with the defect in contrast shade of the pyelon, caused by a stag horn calculus. Contrast added computerized axial tomography of the abdomen and pelvis visualized the pyelon casted concretion spreading throughout the right pyelon, with ureterohydronephrosis with the distal block for passage of the contrast to the distal part of the ureter.

Conclusions: There is no doubt that CA 19-9 level is occasionally elevated in patients with obstructive urolithiasis as it was in our case. In the routine medical praxis, urolithiasis should not be neglected in the differential diagnosis of elevated concentrations of CA 19-9 marker.

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Figures

Figure 1.
Figure 1.
Intravenous pyelogram of the right kidney. (1) Dilated pyelon and initial part of the ureter. (2) Shadow of the double pelvis and ureter on the right side, adjacent to pyelon with calculosis.
Figure 2.
Figure 2.
CT scans of abdomen. Arrows are marking the position of the kidney stone.
See this image and copyright information in PMC

References

    1. Qin XL, Wang ZR, Shi JS, et al. Utility of serum CA19-9 in diagnosis of cholangiocarcinoma: in comparison with CEA. World J Gastroenterol. 2004;10:4274–32. - PMC - PubMed
    1. Katsanos KH, Kitsanou M, Christodoulou DK, Tsianos EV. High CA 19-9 levels in benign bilary tract disease. Report of four cases and review of the literature. Eur J Intern Med. 2002;13:1321–35. - PubMed
    1. Waraya M, Yamashita K, Katagiri H, et al. Preoperative serum CA19-9 and dissected peripancreatic tissue margin as determiners of long-term survival in pancreatic cancer. Ann Surg Oncol. 2009;16:1231–40. - PubMed
    1. Liang B, Zhong L, He Q, et al. Diagnostic accuracy of serum CA19-9 in patients with cholangiocarcinoma. Med Sci Monit. 2015;21:3555–63. - PMC - PubMed
    1. Sheen-Chen SM, Sun CK, Liu YW, et al. Extremely elevated CA19-9 in acute cholangitis. Dig Dis Sci. 2007;52:3140–42. - PubMed

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