Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jul;33(7):76.
doi: 10.1007/s12032-016-0781-5. Epub 2016 Jun 11.

Non-surgical organ preservation strategies for locally advanced laryngeal tumors: what is the Italian attitude? Results of a national survey on behalf of AIRO and AIOM

D Alterio  1 , P Franco  2 , G Numico  3 , L Licitra  4 , M Cossu Rocca  5 , A Ferrari  6 , C Pinto  7 , E G Russi  8 , U Ricardi  2 , B A Jereczek Fossa  6   9
Affiliations

Non-surgical organ preservation strategies for locally advanced laryngeal tumors: what is the Italian attitude? Results of a national survey on behalf of AIRO and AIOM

D Alterio et al. Med Oncol. 2016 Jul.

Abstract

Chemoradiotherapy is the treatment mostly used as organ preservation (OP) strategy worldwide in advanced laryngo-hypopharyngeal cancer. Due to the not homogeneous results of the literature data regarding the pre-treatment assessment and treatment schedule in this setting of patients, the Italian societies of radiation oncology and medical oncology surveyed (by an online survey) their memberships regarding the Italian attitude on larynx preservation in clinical practice. The survey outline addressed different items such as: demographics (11 items), pre-treatment evaluation (12 items), treatment schedules (10 items) and outcomes (3 items). The survey was filled in by 116 clinical oncologists (64 % radiation and 36 % medical oncologists). Results highlighted that pretreatment evaluation was not homogeneous among the respondents. The treatment of choice for the OP program resulted the concurrent chemoradiotherapy (66 %). Induction chemotherapy was proposed mostly in case of aggressive tumors such as advanced stage (T4 or N3) and/or unfavorable primary sites (hypopharynx). Moreover, after induction chemotherapy, for responders patients most participants (46 %) proposed concurrent chemoradiotherapy, while 18 and 19 % proposed radiotherapy alone or radiotherapy and cetuximab, respectively. For patients with stable disease after induction chemotherapy, the respondents declared to suggest surgery, radiotherapy and cetuximab or radiotherapy alone in 38, 32 and 15 % of cases, respectively. Results of the present survey highlighted the variability of therapeutic approaches offered in clinical practice for patients candidate to a larynx OP program. Analysis of abovementioned results may give the chance to modify some clinical attitudes and create the background for future clinical investigation in this field.

Keywords: Chemoradiotherapy; Laryngeal tumor; Organ preservation; Survey.

PubMed Disclaimer

References

    1. Strahlenther Onkol. 2013 Aug;189(8):632-8 - PubMed
    1. Ann Oncol. 2009 May;20(5):921-7 - PubMed
    1. Otolaryngol Head Neck Surg. 1999 Nov;121(5):534-8 - PubMed
    1. Int J Radiat Oncol Biol Phys. 2009 Apr 1;73(5):1293-303 - PubMed
    1. Radiother Oncol. 2014 Jan;110(1):16-24 - PubMed

LinkOut - more resources