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. 2016 Jun;8(6):1062-6.
doi: 10.21037/jtd.2016.04.32.

Do not forget to give thiamine to your septic shock patient!

Jihad Mallat  1 , Malcolm Lemyze  1 , Didier Thevenin  1
Affiliations

Do not forget to give thiamine to your septic shock patient!

Jihad Mallat et al. J Thorac Dis. 2016 Jun.
No abstract available

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Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
The critical role of thiamine in carbohydrate metabolism and its connection with GSH (reduced glutathione) generation. Thiamine, through TPP, is an indispensable cofactor for PDH without which the entry into the Krebs cycle is blocked that leads to lactate accumulation. TPP is also an essential cofactor of the enzymes: α-KDH for conversion of (α-ketoglutarate to succinyl CoA in the Krebs cycle, and Transketolase in the pentose phosphate pathway for regeneration of GSH from oxidized glutathione (GSSG) and energy production. LDH, lactate dehydrogenase. TPP, thiamine pyrophosphate; PDH, pyruvate dehydrogenase; α-KDH, α-ketoglutarate dehydrogenase.
See this image and copyright information in PMC

References

    1. Wooley JA. Characteristics of thiamin and its relevance to the management of heart failure. Nutr Clin Pract 2008;23:487-93. 10.1177/0884533608323430 - DOI - PubMed
    1. Donnino M. Gastrointestinal beriberi: a previously unrecognized syndrome. Ann Intern Med 2004;141:898-9. 10.7326/0003-4819-141-11-200412070-00035 - DOI - PubMed
    1. Sica DA. Loop diuretic therapy, thiamine balance, and heart failure. Congest Heart Fail 2007;13:244-7. 10.1111/j.1527-5299.2007.06260.x - DOI - PubMed
    1. Manzanares W, Hardy G. Thiamine supplementation in the critically ill. Curr Opin Clin Nutr Metab Care 2011;14:610-7. 10.1097/MCO.0b013e32834b8911 - DOI - PubMed
    1. Gangolf M, Czerniecki J, Radermecker M, et al. Thiamine status in humans and content of phosphorylated thiamine derivatives in biopsies and cultured cells. PLoS One 2010;5:e13616. 10.1371/journal.pone.0013616 - DOI - PMC - PubMed

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