Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jun;8(6):1269-73.
doi: 10.21037/jtd.2016.04.13.

Prognostic significance of FoxM1 expression in non-small cell lung cancer

Qing Sun  1 , Min Dong  1 , Yujuan Chen  1 , Jiawei Zhang  1 , Jinpeng Qiao  1 , Xuedan Guo  1
Affiliations

Prognostic significance of FoxM1 expression in non-small cell lung cancer

Qing Sun et al. J Thorac Dis. 2016 Jun.

Abstract

Background: Various studies examined the relationship between FoxM1 overexpression with the clinical outcome in patients with non-small cell lung cancer (NSCLC), but yielded conflicting results.

Methods: Electronic databases updated to Jan 01, 2015 were searched to find relevant studies. A meta-analysis was conducted with eligible studies which quantitatively evaluated the relationship between FoxM1 overexpression and survival of patients with NSCLC Survival data were aggregated and quantitatively analyzed.

Results: We performed a meta-analysis of seven studies (n=860 patients) that evaluated the correlation between FoxM1 overexpression and survival in patients with NSCLC. Combined hazard ratios suggested that FoxM1 overexpression was associated with poor prognosis of overall survival (OS) (HR =1.73, 95% CI: 1.32-2.14) in patients with NSCLC.

Conclusions: FoxM1 overexpression indicates a poor prognosis for patients with NSCLC.

Keywords: FoxM1; lung cancer; meta-analysis; prognosis.

PubMed Disclaimer

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Meta-analysis (Forest plot) of the seven evaluable studies assessing FoxM1 in lung cancer stratified by patient source for overall survival.
Figure 2
Figure 2
Funnel plot of the seven evaluable studies assessing FoxM1 in lung cancer for overall survival.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Siegel R, Ma J, Zou Z, et al. Cancer statistics, 2014. CA Cancer J Clin 2014;64:9-29. 10.3322/caac.21208 - DOI - PubMed
    1. Bernard ME, Clump DA, Lalonde R, et al. Radiation therapy for locally advanced lung cancer. Transl Cancer Res 2015;4:356-71.
    1. Agalioti T, Giannou AD, Stathopoulos GT. Pleural involvement in lung cancer. J Thorac Dis 2015;7:1021-30. - PMC - PubMed
    1. Wang LB, Chuang EY, Lu TP. Identification of predictive biomarkers for ZD-6474 in lung cancer. Transl Cancer Res 2015;4:324-31.
    1. Sahiner I, Vural GU. Positron emission tomography/computerized tomography in lung cancer. Quant Imaging Med Surg 2014;4:195-206. - PMC - PubMed

LinkOut - more resources